.omega.-Aryl-13,14-didehydro-inter-oxa PGE compounds

Details .omega.-Aryl-13,14-didehydro-inter-oxa PGE compounds .omega.-Aryl-13,14-didehydro-inter-oxa PGE compounds

1978-04-28

1979-07-03

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

562465, 562470, C07C17700

Patent

active

041601017

ABSTRACT:
This invention comprises certain analogs of the prostaglandins in which the double bond between C-13 and C-14 is replaced by a triple bond. Also provided in this invention, are novel chemical processes and novel chemical intermediates useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.

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