Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1995-05-24
1997-07-01
Gerstl, Robert
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
558390, C07K25524, A61K 31275
Patent
active
056439474
ABSTRACT:
A class of .omega.-amino-.alpha.-phenylalkanonitrile derivatives is described having use in treatment of cardiovascular dysfunctions such as hypertension. Compounds of most interest are those of the formula: ##STR1## wherein each of R.sub.1 and R.sub.2 is methoxy, R.sub.3 is hydrido, R.sub.4 is isopropyl, R.sub.5 is methyl and R.sub.6 is selected from linear alkyl, phenylpropyl, phenylbutyl and phenylpentyl.
REFERENCES:
patent: 4612329 (1986-09-01), Itoh et al.
patent: 4681970 (1987-07-01), Liang
Blicke, et. al.; J. Org. Chem., 26, (1961), pp. 1826-1831.
DeFeudis, DN & P, 2 (1989), pp. 113-114.
Bovy Philippe R.
Gillet Claude L.
Gorissen Hugo
Snyers Michel P.
Bulock Joseph W.
G. D. Searle & Co.
Gerstl Robert
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