Omega-(4-polyfluoro-2-hydroxy-2-propyl)-2,3,6-substituted-phenox

Details Omega-(4-polyfluoro-2-hydroxy-2-propyl)-2,3,6-substituted-phenox Omega-(4-polyfluoro-2-hydroxy-2-propyl)-2,3,6-substituted-phenox

1979-05-04

1980-04-22

Helfin, Bernard

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

260455R, 26050111, 26050112, 26050116, 260559T, 260559A, 260559R, 2605705S, 260574, 424309, 424316, 424317, 424319, 560 11, 560 12, 560 17, 560 62, 560 42, 562429, 562430, 562431, 562451, 562472, A61K 31235, C07C14713, C07C10172

Patent

active

041995970

ABSTRACT:
Omega-[4-(polyfluoro-2-hydroxy-2-propyl)-2,3,6-substituted-phenoxy and phenylthio]alkanoic acids and compounds related thereto having antihypertensive activity are preparable by reaction of the appropriate 2,3,6-substituted-4-(polyfluoro-2-hydroxy-2-propyl)phenol or thiophenol with an alkyl ester of a bromoalkanoic acid, followed by hydrolysis to the free acid.

REFERENCES:
patent: 3452081 (1969-06-01), Sprague et al.
patent: 3632629 (1972-01-01), Butteau
patent: 3709926 (1973-01-01), Edameera et al.
Stolyarchuk et al., Chem. Absts., 86, 218(c), 1977.

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