.omega.-(4-aryl or heteroarylpiperazine-1-yl)-2-aryl or aralkyl-

Details .omega.-(4-aryl or heteroarylpiperazine-1-yl)-2-aryl or aralkyl- .omega.-(4-aryl or heteroarylpiperazine-1-yl)-2-aryl or aralkyl-

1994-05-24

1995-05-30

Tsang, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544295, 544357, 544360, 544393, 544394, C07D40303, C07D40104, C07D29500, C07D24104

Patent

active

054202787

ABSTRACT:
Piperazine derivatives of formula ##STR1## and their pharmaceutically acceptable acid addition salts are disclosed. In the formula n is 1 or 2, R is hydrogen or lower alkyl, R.sup.1 is an aryl or nitrogen containing heteroaryl radical, R.sup.2 is hydrogen or lower alkyl, R.sup.3 is aryl, C.sub.4-8 alkyl or aryl(lower)alkyl and X is a functionalized group of specified meaning. The compounds exhibit activity as 5-HT.sub.1A antagonists and can be used, into alia, for the treatment of CNS disorders, such as anxiety.

REFERENCES:
patent: 4988814 (1991-01-01), Abou-Gharbia et al.
patent: 5246935 (1993-09-01), Jeppesen et al.

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