(Omega-(4-(2-pyrimidinyl)-1-piperazinyl)alkyl)-1H-azole derivati

Details (Omega-(4-(2-pyrimidinyl)-1-piperazinyl)alkyl)-1H-azole derivati (Omega-(4-(2-pyrimidinyl)-1-piperazinyl)alkyl)-1H-azole derivati

1992-01-24

1993-01-26

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

A61K 3150, A61K 31495

Patent

active

051822814

ABSTRACT:
The present invention relates to the use of the derivatives of general formula I ##STR1## in which: n can have values 1 to 6, and
R represents a hydrogen atom, a halogen, a C.sub.1 to C.sub.4 lower alkyl radical, a heteroaryl radical, a sulpho radical, an N-substituted or N,N-disubstituted sulphamoyl radical, a nitro radical, a hydroxyl radical, an oxo radical, a C.sub.1 to C.sub.4 lower alkoxy radical, a cyano radical, a C.sub.1 to C.sub.4 lower alkylcarboxylate radical, an aryl or substituted aryl radical, or an amino or substituted amino radical of formula ##STR2## in which R.sub.1 and R.sub.2, which may be identical or different, represent a hydrogen atom, an alkyl radical, an aryl radical, an alkylcarbonyl radical, an arylcarbonyl radical, an alkylsulphonyl radical or an arylsulphonyl radical, the alkyl fragments of these radicals containing from 1 to 4 carbon atoms,
and their therapeutically acceptable salts, for the manufacture of medicinal products intended for the treatment of disorders of cognitive funciton, such as presenile dementia, senile dementia, memory dysfunctions, deterioration of awareness and Alzheimer's disease.

REFERENCES:
Chemical Abstracts 114:122411c (1991).
Chemical Abstracts 115:208017m (1941).

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