Organic compounds -- part of the class 532-570 series – Organic compounds – Fatty compounds having an acid moiety which contains the...
Reexamination Certificate
2005-02-08
2005-02-08
Carr, Deborah D. (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Fatty compounds having an acid moiety which contains the...
C514S560000, C514S642000, C424S677000, C424S722000
Reexamination Certificate
active
06852870
ABSTRACT:
The present invention is directed to a method of treating patients with major depression by administering omega-3 fatty acids. These may be administered in a substantially purified form, as part of a pharmaceutical composition, or as part of a larger molecule, e.g., a triacylglycerol, which releases free fatty acid after ingestion by a patient.The present invention is also directed to triacylglycerols which are esterified at the gamma cardon of glycerol to phosphocholine and at either the alpha or beta carbon of glycerol to an omega-3 fatty acid. These “omega-3 phoshatidylcholines” are also used in the treatment of patients with major depression.
REFERENCES:
patent: 4701468 (1987-10-01), Mendy et al.
patent: 5252333 (1993-10-01), Horrobin
patent: 5434183 (1995-07-01), Larsson-Backström
patent: 0 289 204 (1988-11-01), None
patent: 0 289 204 (1988-11-01), None
patent: WO 9428913 (1994-12-01), None
patent: WO 9739759 (1997-10-01), None
Invitation to Pay Additional Fee with a Communication Relating to the Results of the Partial International Search for PCT/US03/05926.
Adams, J., “Literature Review of Essential Fatty Acids”,puterakembara.org, retrieved on Jul. 23, 2003.
Cohen, et al., “Lecithin in Mania: A Preliminary Report”,Am J Psychiatry137, 242-243, 1980.
Cohen, et al., “Lecithin in the Treatment of Mania: Double-Blind Placebo-Controlled Trials”,Am J Psychiatry139, 1162-1164, 1982.
Dimmitt, S.B., “Recent Insights into Dietary Fats and Cardiovascular Disease”,Clin. Exp. Pharmacol. Physiol.22, 204-8, 1995 (abstract only).
Locke, et al., “Omega-3 Fatty Acids in Major Depression”,World Review of Nutrition and Dietetics, 89: 173-185, 2001.
Maidment, I., “Are Fish Oils an Effective Therapy in Mental Illness—an Analysis of the Data”,Acta Psychiatr Scand., 102: 3-11, 2000.
Mischoulon, et al., “Docosahexanoic Acid and ω-3 Fatty Acids in Depression”,The Psychiatric Clinics of North America, 23(4): 785-794, 2000.
Puri, et., “The Effects of Olive Oil on ω3 Fatty Acids and Mood Disorders”,Arch Gen Psychiatry57, 2000.
Puri, et al., “Eicosapentaenoic Acid in Treatment-Resistant Depression”,Archives of General Psychiatry, 59(1): 91-92, 2002.
Schreier, H., “Mania Responsive to Lecithin in a 13-Year-Old Girl”,Am J Psychiatri139, 108-110, 1982.
Sperling, R., “Dietary Omega-3 Fatty Acids: Effects on Lipid Mediators of Inflammation and Rheumatoid Arthritis”,Rheumatic Disease Clinics of North America17, 373-389, 1991.
Sperling, et al., “Dietary ω-3 Polyunsaturated Fatty Acids Inhibit Phosphoinositide Formation and Chemotaxis in Neutrophils”,J. Clin. Invest91, 651-660, 1993.
Stoll, et al., “Choline Ingestion Increases the Resonance of Choline-Containing Compounds in Human Brain: An In Vivo Proton Magnetic Resonance Study”,Society of Biological Psychiatry37, 170-174, 1995.
Stoll, et al., “Omega 3 Fatty Acids in Bipolar Disorder”,Arch Gen. Psychiatry, 56: 407-412, 1999.
Stoll, et al., “Omega-3 Fatty Acids and Bipolar Disorder: A Review”,Prostaglandins, Leukotrienes and Essential Fatty Acids, 60: 329-337, 1999.
Stoll, et al., “Methodological Considerations in Clinical Studies of ω3 Fatty Acids in Major Depression and Bipolar Disorder”,World Review of Nutrition and Dietetics, 88: 58-67, 2001.
Carr Deborah D.
Choate Hall & Stewart
Rosen Valarie B.
Stoll Andrew
LandOfFree
Omega-3 fatty acids in the treatment of depression does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Omega-3 fatty acids in the treatment of depression, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Omega-3 fatty acids in the treatment of depression will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3455221