Omega 3 fatty acids in the prevention of ventricular fibrillatio

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

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A01N 3700, A61K 3120

Patent

active

057600813

ABSTRACT:
Methods and compositions for the prevention of imminent ventricular fibrillation are disclosed. The composition comprises eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), or a mixture of EPA and DHA. The composition may be administered by intravenous infusion, intracardial injection or both in a patient who presents symptoms of a condition, such as myocardial infarction, which may immediately lead to ventricular fibrillation.

REFERENCES:
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Hock et al., "Influence of dietary n-3 fatty acids on myocardial ischemia and reperfusion", American Journal of Physiology, vol. 259, No. 5, Nov. 1990.
Kamp et al., "pH gradients across phospholipid membranes caused by fast flip-flop of un-ionized fatty acids", Proc. Natl. Acad. Sci. USA, vol. 89, pp. 11367-11370, Dec. 1992, Biophysics.
Kang and Leaf, "Effects of long-chain polyunsaturated fatty acids on the contraction of neonatal rat cardiac myocytes," Proc. Natl. Acad. Sci. USA 91:9886-9890, 1994.
Xiao et al., "Blocking effects of polyunsaturated fatty acids on Na + channels of neonatal rat ventricular myocytes," Proc. Natl. Acad. Sci. USA, 1995.
Kang, Xiao and Leaf, "Free, long-chain polynsaturated fatty acids reduce membrane electrical excitability in neonatal rat cardiac myocytes," Proc. Natl. Acad. Sci. USA 92:3997-4001, 1995.

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