Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-03-28
1999-02-23
Feisee, Lila
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435325, 4353201, 435 711, 536 235, 536 231, 530350, C12N 1500
Patent
active
058742433
ABSTRACT:
OLRCC15 receptor polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing OLRCC15 receptor polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.
REFERENCES:
Hillier et al., The WashU-Merck EST Project, Genbank accession No. AA042813, Sep. 1996.
George et al., Macromolecular sequencing and synthesis, Alan Riss , pp. 127-149, 1988.
EST 961576.
EST 961584.
Accession L34074.
Accession M84005.
Accession U50948.
Nef et al., "Spatial pattern of receptor expression in the olfactory epithelium", Proc. Natl. Acad. Sci. USA, vol. 89, pp. 8948-8952, Oct. 1992.
Thomas et al., "Chemoreceptors expressed in taste, olfactory and male reproductive tissue", Gene, vol. 178, pp. 1-5, (1996).
Parmentier et al., "Expression of members of the putative olfactory receptory gene family in mammalian germ cells", Nature, vol. 355, pp. 453-455, Jan. 1992.
Vanderhaeghen et al, "Specific Repertoire of Olfactory Receptor Genes in the Male Germ Cells of Several Mammalian Species", Genomics, vol. 39, pp. 239-246 (1997).
Drutel et al., "Cloning of OL1, a Putative Olfactory Receptor and its Expression in the Developing Rat Heart", Receptors and Channels, vol. 3, pp. 33-40 (1995).
Macina Roberto Anibal
Sathe Ganesh Madhusudan
Feisee Lila
Han William T.
King William T.
Lazar-Wesley Eliane
SmithKline Beecham Corporation
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