Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1983-08-15
1987-04-21
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514210, 514211, 514212, 514218, 514222, 514226, 514231, 514254, 540468, 540544, 540546, 540547, 540575, 540600, 544 54, 544 586, 544 587, 544361, 546 62, 546 65, 546 80, 546 92, A61K 31495, C07D41714
Patent
active
046597344
ABSTRACT:
A compound of the formula ##STR1## R.sub.1 is hydrogen, alkali metal, alkaline earth metal, lower alkyl, pivaloyloxymethyl or phthalidyl;
R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are the same or different and are hydrogen, halogen, lower alkoxy or ##STR2## wherein R.sub.6 and R.sub.7 are lower alkyl or R.sub.6 and R.sub.7 together with the nitrogen atom to which they are attached form a five- to seven-membered unsubstituted or substituted heterocyclic ring containing said nitrogen atom as the sole hetero atom or containing nitrogen, sulfur or oxygen as additional hetereo atoms;
A is a saturated or unsaturated hydrocarbon chain of one to five carbon atoms, unsubstituted or substituted by lower alkyl; lower alkoxy; lower alkylthio; hydroxy; halogen; lower alkyl substituted by halogen, amino, loweralkoxycarbonyl, carboxy, lower-alkoxy, loweralkylthio, loweracyloxy or hydroxy; loweralkylamino; carboxy; nitro; cyano; carbonyl; imino; or by substituted or unsubstituted phenyl, phenylthio, phenylamino or phenoxy; and
R.sub.2 and R.sub.3 or R.sub.3 and R.sub.4 or R.sub.4 and R.sub.5 together may be alkylenedioxy of 1 to 5 carbon atoms which form a ring with the carbon atoms to which they are attached; or a pharmaceutically acceptable salt thereof.
REFERENCES:
patent: 4426381 (1984-01-01), Matsumura et al.
patent: 4550104 (1985-10-01), Mich et al.
Chu, et al., "Chemical Abstracts", vol. 105(7), 1986, Col. 105:60558j.
Enomoto Hiroshi
Kise Masahiro
Kitano Masahiko
Morita Iwao
Ozaki Masakuni
Hollrah Glennon H.
Nippon Shinyaku Co. Ltd.
Turnipseed James H.
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