Oligosaccharides reactive with hyaluronan-binding protein and th

Details Oligosaccharides reactive with hyaluronan-binding protein and th Oligosaccharides reactive with hyaluronan-binding protein and th

1994-09-14

1999-05-11

Fonda, Kathleen K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 2, 514 4, 514 61, A61K31/715

Patent

active

059027959

ABSTRACT:
Hyaluronan-binding protein (HABP) is expressed on the cell surface during tumor cell and endothelial cell migration and during capillary-like tubule formation. Monoclonal antibodies and hyaluronan oligosaccharides are described which specifically recognize HABP and can be used to (1) inhibit tumor growth by preventing tumor vascularization, (2) inhibit tumor cell migration and (3) image tumors.

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