Oligosaccharides obtained by heparin depolymerization having ant

Details Oligosaccharides obtained by heparin depolymerization having ant Oligosaccharides obtained by heparin depolymerization having ant

1988-09-21

1990-06-12

Rollins, John W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 21, 514822, A61K 31725, C08B 3710

Patent

active

049333267

ABSTRACT:
Heparin fractions which are a mixture of oligosaccharides containing 6-12 monosaccharides are described. The oligosaccharides contain reducing end groups composed of iduronic acid 2-sulfate or glucosamine N, 6-disulfate. The end group monosaccharides contain the reducing anomeric carbons. The SO.sub.3.sup.- /COO.sup.- ratio is essentially the same as in heparin. The method of preparation is a depolymerization initiated by free radicals. One fraction is a heparin fragment with a molecular weight (MWw) of 2,100 daltons (+10%). The compound contains 6-8 monosaccharides, has the same SO.sub.3.sup.- /COO.sup.- ratio as the parent heparin and has platelet anti-aggregating activity, arterial and venous antithrombotic action, fibrinolytic and antiatherosclerotic activity. It exhibits poor anti factor Xa activity and no anticoagulant action.

REFERENCES:
patent: 4303651 (1981-12-01), Lindahl et al.
patent: 4351938 (1982-09-01), Barnett
patent: 4500519 (1985-02-01), Lormeau et al.

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