Oligosaccharides having selective anticoagulation activity

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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536 175, 536 21, 514 56, A61K 31725, C08B 3710

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active

044965508

ABSTRACT:
The invention relates to an oligosaccharide which contains 4-8 monosaccharide units and which is characterized in that it contains at least one glucosamine unit which is 3-0-sulfated, and at least one additional glucosamine unit, whereby these units are linked via an intermediate monosaccharide unit, which is bound to the reducing end of the 3-0-sulfated glucosamine unit. The invention further relates to a pharmaceutical composition containing one or more such oligosaccharides, and to a process for the preparation of these oligosaccharides.

REFERENCES:
patent: 4281108 (1981-07-01), Fussi
patent: 4303651 (1981-12-01), Lindahl et al.
patent: 4401662 (1983-08-01), Lormeau et al.
patent: 4401758 (1983-08-01), Lormeau et al.
Chem. Abstracts 93:142792d, (1980).
Chem. Abstracts 86:364x, (1977).
Chem. Abstracts 91:85818z, (1979).
Chem. Abstracts 86:67137u, (1977).
Chem. Abstracts 94:44880g, (1981).
Chem. Abstracts 85:89445z, (1976).
Linkler et al, Biochemistry 11(1), 1972, pp. 563-568.
Meyer, Carbohydrate Research, 88(1), 1981, pp. C1-C4.

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