Oligosaccharides having anti-Xa activity and pharmaceutical comp

Details Oligosaccharides having anti-Xa activity and pharmaceutical comp Oligosaccharides having anti-Xa activity and pharmaceutical comp

1995-12-19

1998-04-14

Fonda, Kathleen K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 175, 536 21, A61K 31725, C08B 3710

Patent

active

RE0357707

ABSTRACT:
Oligosaccharides obtainable from heparin including heparinic constituents of molecular weights ranging from 2000 to 50,000. Said fractions have a Yin-Wessler titer and a USP titer in a ratio of at least 30. They consist of chains constituted by no more than 8 saccharidic moities. They possess a strong antithrombotic activity and are then useful as antithrombotic drugs.

REFERENCES:
patent: 3506642 (1970-04-01), Koh et al.
patent: 3985871 (1976-10-01), Butti et al.
patent: 4122250 (1978-10-01), Schmer
patent: 4175182 (1979-11-01), Schmer
patent: 4213962 (1980-07-01), Miura et al.
patent: 4281108 (1981-07-01), Fussi
Choay et al. Thrombosis Research 1980, 18(3/4), 573-578.

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