Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1993-07-12
1996-05-07
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 61, 536115, 536120, 536124, A61K 3170, C07H 306
Patent
active
055146589
ABSTRACT:
A method for obtaining oligosaccharides starts with allylation of position (3') of .beta.-lactosides followed by controlled benzylation, which leads to perbenzylated and partially benzylated compounds. The latter are glycosylated at position 3, not benzylated, with a donor of .varies.-fucopyranosyl to yield protected trisaccharides. These and perbenzylated .beta.-Lactosides are deallylated and, later, are glycosylated with 2-azido-2-deoxy-.varies.-D-galactopyranosyl to yield protected tetrasaccharides and trisaccharides, respectively. The debenzylation of said products accompanied by the reduction of the azido group and simultaneous acetylation of the amino group produces intermediary products which, by O-deacetylation, leads respectively to the final tetrasaccharides and trisaccharides. The resulting oligosaccharides produce inhibition of mitosis in astrocytes and tumoral cells of the nervous system and, for this reason, can be used for controlling glial scar and for treatment of tumors of the nervous system.
REFERENCES:
patent: 5002759 (1991-03-01), Gaffar et al.
patent: 5118521 (1992-06-01), Sonoike et al.
Santos-Benito et al. Carbohyd. Res. 1992, 230(1), 185-190. pub. date Jun. 12, 1992.
Fernandez-Mayoralas Alfonso
Martin Lomas Maanuel
Nieto Sampedro Manuel
Santos Benito Fernando F.
Consejo Superior Investigaciones Cientificas
Fonda Kathleen Kahler
Robinson Douglas W.
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