Oligosaccharide heparin fragments as inhibitors of complement ca

Details Oligosaccharide heparin fragments as inhibitors of complement ca Oligosaccharide heparin fragments as inhibitors of complement ca

1988-08-02

1990-04-10

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 54, 536118, 536126, 536122, A01N 4304, C08B 3710, C07G 3700, C07H 100

Patent

active

049162195

ABSTRACT:
There is disclosed oligosaccharide compounds having heparin-like anticomplement activity and reduced anticoagulant activity as compared with heparin on a weight or molar basis. The oligosaccharide compounds have at least 5 and no greater than 25 saccharide units. The oligosaccharides can have an even nuber of saccharide units with a terminus nonreducing sugar, or an odd number of saccharide units without a terminus nonreducing sugar. There is also disclosed anticomplement pharmaceutical compositions with reduced anticoagulant side effect activity and a process for preparing the oligosaccharide compounds.

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Sharath et al., Immunopharmacology 9:73-80, 1985.
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