Oligosaccharide enzyme substrates and inhibitors: methods and co

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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536 41, 536 172, 536 173, 536 179, 536118, 536119, C07H 504, C07H 510

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054611431

ABSTRACT:
Oligosaccharide compounds that are substrates and inhibitors of glycosyltransferase and glycosidase enzymes and compositions containing such compounds are disclosed. A method of glycosylation is also disclosed. An E. coli transformed with phagemid CMPSIL-1, which phagemid comprises a gene for a modified CMP-sialic acid synthetase enzyme, which transformed E. coli has the ATCC accession No. 68531 is also provided.

REFERENCES:
patent: 4918009 (1990-04-01), Nilsson
patent: 5039523 (1991-08-01), Payne et al.
patent: 5045469 (1991-09-01), Payne et al.
patent: 5180674 (1993-01-01), Roth
Roseman et al., Chem. Phys. Lipids, 51:270-297 (1970).
Flowers, Meth. Enzymol., 138:359-404 (1987).
Paulsen, Angew. Chemie, 21(3):155-224 (1982).
Bock et al., Carb. Res., 130:125-134 (1984).
Evans et al., Tet. Letters, 26(11):1465-1468 (1985).
Hindsgaul et al., J. Biol. Chem., 266(27):17858 (1991).
Mizuochi et al., J. Biol. Chem., 264(13):13834-13839 (1989).
Danishefsky, S. J. J. Am. Chem. Soc., 111:6656 (1989).
Okamoto et al., Tetrahedron, 46:5835 (1990).
Ito et al., Tetrahedron 46:89 (1990).
Toone et al., Tetrahedron, 45:5365 (1989).
Beyer, et al., Adv. Enzymol., 52:23 (1981).
Schanbacher, et al., J. Biol. Chem., 245:5057 (1970).
Berliner, et al., Mol. Cell. Biochem., 62:37 (1984).
Nunez, et al., Biochemistry, 19:495 (1980).
Barker, et al., J. Biol. Chem., 247:7135 (1972).
Babad, et al., J. Biol. Chem., 241:2672 (1966).
Schauer et al., Biochem. Soc. Symp., 40:87 (1974).
Durrwachter et al., J. Org. Chem., 1988, 53, 4175.
Pederson et al., Tetrahedron Lett. 1988, 29, 4645.
Von der Osten et al., J. Am. Chem. Soc. 1989, 111, 3924.
Pederson et al., Heterocycles 1989, 28, 477.
Pederson et al., J. Org. Chem. 1990 55, 489.
Weinreb et al., Tetrahedron Lett. 1986, 2099.
Gross et al., Eur. J. Biochem., 168:595 (1987).
Vijay et al., J. Biol. Chem., 250(1) 164 (1975).
Zapata et al., J. Biol. Chem., 264(25) 14769 (1989).
Higa et al., J. Biol. Chem., 260(15):8838 (1985).
Huse et al., Science, 246:1275 (1989).
Paulson, et al., 3. Biol. Chem., 264:17615 (1989).
Aoki, et al., EMBO, 9:3171 (1990).
Shima, et al., J. Ferm. Bioena., 68:75 (1989).
Ernst et al., J. Biol. Chem., 264:3436 (1989).
Masibay et al., Proc. Natl. Acad. Sci. U.S.A., 86:5733 (1989).
Toghrol et al., Biochemistry, 29:2349 (1990).
Joziasse et al., Eur. J. Biochem., 191:75 (1990).
Kajimoto, et al., J. Am. Chem. Soc., 113:6196 (1991).
Lowe, et al., Cell, 63:475 (1990).
Corey, et al., J. Ora. Chem., 38:3224 (1973).
Schweden et al., Arch. Biochem. Biophys., 1986, 248, 335.
Dale et al., Biochemistry, 1985, 24, 3530.
Short et al., TNucleic Acids Res., 16:7583 (1988).
Van et al., J. Biol. Chem., 262:17556 (1987).
Ozaki et al., J. Am. Chem. Soc. 1990, 112, 4970).
Lowe et al., Genes and Development, 4:1288 (1990).
Tabor et al., Proc. Natl. Acad. Sci. USA, 82:1074 (1985).
Ichikawa et al., J. Am. Chem. Soc., 113:4698 (1991).
Shames et al., Glycobiology, 1:87 (1991).
Auge et al., Tetrahed. Lett., 29:789 (1988).
Kean et al., Methods Enzymol., 8:208 (1966).
Roseman, S. Proc. Natl. Acad. Sci., 48:437 (1962).
Gross et al., Eur. J. Biochem., 117:583 (1988).
Zhong et al., J. Am. Chem. Soc., 113:683 (1991).
Auge et al., Tetrahed. Lett., 25:4663 (1984).
Kim et al., J. Am. Chem. Soc., 110:6481 (1988).
Auge et al., New J. Chem., 12:733 (1988).
Brossmer et al., Biochem. Biophy. Res. Comm., 96:1282 (1980).
Auge et al., Tetrahedron, 46:201 (1990).
Auge et al., Tetrahed. Lett., 30:2217 (1989).
Dumas et al., Bioorg. Med. Chem, 1:425 (1991).
Sharma et al., Carb. Res., 175:25 (1988).
Noller, Chemistry of Organic Compounds, W. B. Saunders Company, Philadelphia, 1951, p. 35.
Ichikawa et al., J. Am. Chem. Soc., 114:9283-9298 (1992).
Ichikawa et al., Anal. Biochem., 202:215-238 (1992).
Ainsberg, Attorney's Dictionary of Patent Claims, vol. 1, Matthew Bender, New York, pp. P-81 and P-82, and C-88 (1993).
Stryer, Biochemistry, vol. 3, W. H. Freeman and Co., New York pp. 337-338 (1988).
U.S. Patent No. 4,387,088, Official Gazette entry.

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