Oligoribonucleotides for cleaving RNA

Details Oligoribonucleotides for cleaving RNA Oligoribonucleotides for cleaving RNA

1996-06-06

1999-04-27

LeGuyader, John L.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

435 6, 435375, 536 231, 536 245, C12N 1500, C12Q 168, C07H 2104

Patent

active

058980318

ABSTRACT:
Oligomeric compounds including oligoribonucleotides and oligoribonucleosides are provided that have subsequences of 2-pentoribofuranosyl nucleosides that activate dsRNase. The oligoribonucleotides and oligoribonucleosides can include substituent groups for increasing binding affinity to complementary nucleic acid strand as well as substituent groups for increasing nuclease resistance. The oligomeric compounds are useful for diagnostics and other research purposes, for modulating the expression of a protein in organisms, and for the diagnosis, detection and treatment of other conditions susceptible to oligonucleotide therapeutics.

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