Oligopetides with cyclic proline-analogous amino acids

Details Oligopetides with cyclic proline-analogous amino acids Oligopetides with cyclic proline-analogous amino acids

1989-06-01

1993-04-27

Cashion, Jr., Merrell C.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Tripeptides, e.g., tripeptide thyroliberin , etc.

5483561, 930 20, A61K 3702, C07D23100

Patent

active

052063437

ABSTRACT:
The invention relates to compounds of the formula I ##STR1## in which A denotes an optionally substituted radical from the series comprising alkyl, acyl, cycloalkyl, aryl and heteroaryl; Cyc represents an optionally substituted heterocyclic carbonyl compound; D represents NH, NCH.sub.3, O or CH.sub.2 ; E represents CHOH, CO, SO or optionally N-substituted C.dbd.NH; F represents O, NH, NCH.sub.3 or a bond; R.sup.4 denotes an optionally substituted radical from the series comprising alkyl, cycloalkyl, aryl and heteroaryl; and R.sup.8 denotes hydrogen or optionally substituted alkyl, to a process for the preparation thereof, and to the use thereof as inhibitors of prolyl hydroxylase.

REFERENCES:
patent: 4425333 (1984-01-01), Iwao et al.
patent: 4761399 (1988-08-01), Pilotto et al.
patent: 4840936 (1989-06-01), Della Bella et al.
patent: 4952596 (1990-08-01), Della Bella et al.
patent: 4971993 (1990-11-01), Kurauchi et al.
Fairweather, R., and Jones, J. H., J Chem. Soc. Perkins I, 1972, pp. 2475-2481.
Gunzler, V. et al., J Biol. Chem. 263, pp. 19498-19504 (1988).

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