Oligopeptides, the preparation and use thereof

Details Oligopeptides, the preparation and use thereof Oligopeptides, the preparation and use thereof

1995-11-09

1998-09-15

Tsang, Cecilia J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

4 to 5 amino acid residues in defined sequence

530329, 514 17, C07K 706, A61K 3803

Patent

active

058079840

ABSTRACT:
Novel peptides of the formula

REFERENCES:
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patent: 4879278 (1989-11-01), Petttit et al.
patent: 5502032 (1996-03-01), Haupt et al.
patent: 5504191 (1996-04-01), Pettit et al.
patent: 5530097 (1996-06-01), Pettit et al.
Rudinger, J `Characteristics of amino acids as components of peptide hormones sequence` in Peptide Hormones, (ed. J.A. Parsons). University Park Press, Baltimore, pp. 1-7, 1976.
Smith et al. `Pre-clinical anti-tumor activity of novel water soluble Dolastatin 15 analog (LU103793)`, Proceedings of the American Association for Cancer Research Annual Meeting 36(0). 1995. p. 393 #2345.
Pettit, G. R., et al., "The Isolation and Structure of a Remarkable Marine Animal Antineoplastic Constituent: Dolastatin 10," J, Am. Chem. Soc., 109: 6883-6885 (1987).
Bai, R., et al., "Structure-Activity Studies with Chiral Isomers and with Segments of the Antimitotic Marine Peptide Dolastatin 10," Biochemical Pharmacology, 40(8): 1859-1864 (1990).
Pettit, G. R, et al., "Antineoplastic Agents. 220. Synthesis of Natural (-)-Dolastatin 15, " J. Am. Chem. Soc., 113: 6692-6693 (1991).
Pettit, G. R., et al., "Isolation and Structure of the Cytostatic Linear Depsipeptide Dolastatin 15," J. Org. Chem., 54: 6005-6006 (1989).
Bai, R., et al., "Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricularia. Interaction with tubulin and effects on cellular microtubles," 1-Pharamacology Abstract 117: 103735g p. 41 (1992).
Pettit, G. R., et al., "Isolation and Structure of the Cytostatic Depsipeptide Dolastatin 13 from the Sea Hare Dolabella auricularia," J. Am. Chem. Soc., 111(3): 5015-5017 (1989).
Pettit, G. R., et al., "Antineoplastic agents 337. Synthesis of Dolastatin-10 Structural Modifications," Anti-Cancer Drug Design, 10: 529-544 (1995).
Miyazaki, K., et al., "Synthesis and Anti-Tumor Activity of Novel Dolastatin-10 Analogs," Chem. Pharm. Bull., 43(10: 1706-1718 (1995).

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