Oligopeptides and intermediates and processes for their manufact

Details Oligopeptides and intermediates and processes for their manufact Oligopeptides and intermediates and processes for their manufact

1986-01-15

1988-01-19

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 530324, 530307, A61K 3724, C07K 710

Patent

active

047204834

ABSTRACT:
Described are peptides that have, as partial sequence of a larger peptide, or exclusively, the amino acid sequence of the formula I ##STR1## in which the cysteine residues can form intra- or inter-molecular disulphide bridges, and derivatives thereof having an amidated terminal carboxy group and/or an acylated terminal amino group, and their salts, DNA sequences that code for the mentioned peptides, micro-organisms that contain these DNA sequences, processes for the manufacture thereof, pharmaceutical preparations that contain the mentioned peptides in the form of their amides, and the use of these peptide-amides for the treatment of coronary circulation disorders and bone metabolism disorders.

REFERENCES:
patent: 4530838 (1985-07-01), Evans et al.
patent: 4549986 (1985-10-01), Evans et al.
The Merck Index, 10th Ed., pp. 515-516.
Steenberg, FEBS Letter 183: 403-407 (1985).
Hoppener, Human Genetics 70: 259-263 (1985).
Morris, Nature 308: 746-748 (1984).
Brain, Nature 313, pp. 54-56 (1985).

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