Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Tripeptides – e.g. – tripeptide thyroliberin – etc.
Patent
1987-07-15
1990-03-27
Moskowitz, Margaret
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Tripeptides, e.g., tripeptide thyroliberin , etc.
530329, 530330, 514 18, 514 19, C07C10352, C07K 706, A61K 3700
Patent
active
049121995
ABSTRACT:
Oligopeptide anticancer and antiviral agents are represented by the formula:
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patent: 4540683 (1985-09-01), DeBarbieri et al.
Lown et al., "Molecular Recognition between Oligopeptides and Nucleic Acids: Novel Imidazole-Containing Oligopeptides Related to Netropsin that Exhibit Altered DNA Sequence Specificity," Biochemistry, vol., 25, pp. 7408-7416, 1986.
Martin et al., "Mechanisms of Antiviral Immunity Induced by Vaccinia Virus Recombinant Expressing Herpes Simplex Virus Type 1 Glyroprote D: Cytotoxic T Cells", Journal of Virology, vol. 61, pp. 726-734, 1987.
Lown et al., "Structure-Activity Relationship of Novel Oligopeptide Antiviral and Antitumor Agents Related to Netropsin and Distamycin," J. Med. Chem. vol. 29, pp. 1210-1214, 1986.
Lown et al., "Efficient Total Synthesis of the Oligopeptide Antibiotics Netropsin and Distamycin", J. Org. Chem. vol. 50, pp. 3774-3779, 1985.
Efficient Total Syntheses of the Oligopeptide Antibiotics Netropsin and Distamycin, Lown and Krowicki, American Chemical Society, J. Org. Chem., vol. 50, No. 20, 1985, pp. 3774-3779.
Youngquist et al., "Sequence-Specific Recognition of B-DNA by Oligo(N-Methylpyrrolecarboxamide)s," Proc. Natl. Acad. Sci. U.S.A. (1985), 82:2565-2569.
Krowicki Krzysztof
Lown J. William
Mohamed Abdel A.
Moskowitz Margaret
The Governors of the University of Alberta
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