Oligopeptide antagonist of interleukin-6

Details Oligopeptide antagonist of interleukin-6 Oligopeptide antagonist of interleukin-6

2007-04-10

2007-04-10

Chism, B. Dell (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S300000

Reexamination Certificate

active

11195674

ABSTRACT:
The present invention provides an antagonist peptide of interleukin-6 (IL-6), wherein the peptide comprises a amino acid sequence which is selected from the group consisting of SEQ ID NO: 5, SEQ ID NO: 6 and SEQ ID NO: 7. The peptide of the invention is able to specifically bind IL-6R and compete for the binding of IL-6 to IL-6R, to block IL-6-induced signal transduction and therefore effectively inhibits IL-6-mediated antiapotopsis and angiogenesis, and further inhibits IL-6-mediated tumor growth.

REFERENCES:
patent: 2004/0123343 (2004-06-01), La Rosa et al.
Su et al., “A Novel Peptide Specifically Binding to Interleukin-6 Receptor (gp80) Inhibits Angiogenesis and Tumor Growth”, Cancer Res, vol. 65, pp. 4827-4835, Jun. 1, 2005.
Salanoubat M. et al. “Genome Sequence of the Plant Pathogen Ralstonia solanacearum” 2002, Nature, vol. 415, pp. 497-502.
Clinical Cancer Research, vol. 9, Oct. 15, 2003, pp. 4653-4665, Trikha et al.

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