Oligonucleotides with substantially chirally pure phosphorothioa

Details Oligonucleotides with substantially chirally pure phosphorothioa Oligonucleotides with substantially chirally pure phosphorothioa

1994-08-29

1996-04-09

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 42, 514 43, 514 45, 514 46, 536 245, 536 2533, 536 2534, A61K 3170, C07H 2100

Patent

active

055062121

ABSTRACT:
Sequence specific phosphorothioate oligonucleotides comprising nucleoside units which are joined together by either substantially all Sp or substantially all Rp phosphorothioate intersugar linkages are provided. Such sequence specific phosphorothioate oligonucleotides having substantially chirally pure intersugar linkages are prepared by enzymatic synthesis from nucleoside 5'-O-(1-thiotriphosphates).

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