Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1996-03-11
1998-02-24
Marschel, Ardin H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
435 6, 436501, 536 231, 536 241, 536 243, 536 2431, 536 2432, 536 2433, C12Q 168, A61K 4800
Patent
active
057212180
ABSTRACT:
Oligonucleotides having tandem sequences of inverted polarity, i.e., oligonucleotides comprising regions of the formula:
REFERENCES:
patent: 4957858 (1990-09-01), Chu et al.
patent: 5399676 (1995-03-01), Froehler
Chu et al., "Derivatization of unprotected polynucleotides," Nuc Acids Res 11:6513-6529 (1983).
Chu et al., "Synthesis of an amplifiable reporter RNA for bioassays," Nuc Acids Res 14:5591-5603 (1986).
Cooney et al., "Site-Specific Oligonucleotide Binding Represses Transcription of the Human c-myc Gene In Vitro," Science 241:456-459 (1988).
Gilham, P.T., "The Synthesis of Celluloses Containing Covalently Bound Nucleotides, Polynucleotides, and Nucleic Acids," Biochem 7:2809-2813 (1968).
Horne et al., "Recognition of Mixed-Sequence Duplex DNA by Alternate-Strand Triple-Helix Formation," J Am Chem Soc 112:2435-2437 (1990).
Moser et al., "Sequence-Specific Cleavage of Double-Helical DNA by Triple Helix Formation," Science 238:645-650 (1987).
Praseuth et al., "Sequence-specific binding and photocrosslinking of a and b oligodeoxynucleotides to the major groove of DNA via triple-helix formation," Proc Natl Acad Sci 85:1349-1353 (1988).
van de Sande, "Parallel Stranded DNA," Science 241:551-557 (1988).
Gilead Sciences, Inc.
Marschel Ardin H.
Muenchau Daryl D.
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