Oligonucleotides with inverted polarity

Details Oligonucleotides with inverted polarity Oligonucleotides with inverted polarity

1990-07-30

1995-03-21

Fleisher, Mindy B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 536 245, 536 284, 536 267, 536 243, C07H 2102, C07H 2104, C12Q 168

Patent

active

053996763

ABSTRACT:
Oligonucleotides having tandem sequences of inverted polarity, i.e., oligonucleotides comprising regions of the formula: ##STR1## wherein --C-- symbolizes any method of coupling the nucleotide sequence of opposite polarity,
are useful for forming an extended triple helix with a double-helical nucleotide duplex. The inverted polarity also stabilizes the single-strand oligonucleotides to exonuclease degradation.

REFERENCES:
patent: 4894325 (1990-01-01), Englehardt et al.
patent: 4957858 (1988-04-01), Chu et al.
Gilman, Bichemistry (1968) 7(8):28-09-2813.
Moser et al., Science (1987) 238:645-650.
Cooney et al., Science (1988) 241:456-459.
Capobianco et al., Nucleic Acids Res. (1990) 18(9):2661-2669.
Horne et al., J. Amer. Chem. Soc. (1990) 112:2435-2437.
Van De Sande et al., Science (1988) 241:551-557.
Praseuth, D., et al., Proc. Natl. Acad. Sci. USA (1988) 85:1349-1353.
Gilham Adv. Exp. Med. Biol. 42:173-185 (1974).
Chu et al Nucleic Acids Res 11(18):6513-29 (1983).
Chu et al Nucl Acids Res 14(14):5591-03 (1986).

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