Oligonucleotides with inverted polarity

Details Oligonucleotides with inverted polarity Oligonucleotides with inverted polarity

1993-11-16

1996-06-18

Jones, W. Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 435810, 436501, 536 221, 536 231, 536 241, 536 243, 536 2431, 536 2432, 536 2433, 935 77, 935 78, 935 88, C07H 2100

Patent

active

055278990

ABSTRACT:
Oligonucleotides having tandem sequences of inverted polarity, i.e., oligonucleotides comprising regions of the formula: ##STR1## wherein --C-- symbolizes any method of coupling the nucleotide sequence of opposite polarity, are useful for forming an extended triple helix with a double-helical nucleotide duplex. The inverted polarity also stabilizes the single-strand oligonucleotides to exonuclease degradation.

REFERENCES:
Praseuth, D., Proc. Natl. Acad. Sci. (1988) 85:1349-1353.
Moser et al., Sequence-Specific Cleavage of Double Helical DNA by Triple Helix Formation; Science (1987) 238:645-650.
Cooney et al., Science (1988) 241:456-459.
Capobianco et al., Nucleic Acids Res. (1990) 18(9):2661-2669.
Van De Sande et al., Science (1988) 241:551-557.
Gilman, Bichemistry (1968) 7(8):2809-2813.
Horne et al., J. Am. Chem. Soc., (1990) 112:2435-2437.

Affiliated with

Also associated with

Rating

Oligonucleotides with inverted polarity does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Oligonucleotides with inverted polarity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Oligonucleotides with inverted polarity will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-223771