Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1994-07-19
1997-05-13
Low, Christopher S. F.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 241, 536 221, 536 2372, 536 253, 435 911, 435 9132, 435 9133, 435 915, 435 9151, 935 3, 935 5, 935 8, 935 9, C07H 2102, C07H 2104, A61K 3170
Patent
active
056294131
ABSTRACT:
The present invention features compounds and methods for inhibiting propagation of human immunodeficiency virus (HIV). Preferred HIV target sites are identified and oligonucleotides designed to hybridize to a target site are described. The preferred use of the oligonucleotides is as an anti-HIV agent to inhibit HIV propagation in a patient infected with HIV. Other uses of the present invention include detecting the presence of HIV by using the oligonucleotides as detection probes or amplification primers, and measuring the ability of an oligonucleotide to inhibit HIV propagation to evaluate its suitability as an anti-HIV agent for a phenotype of HIV or diagnose the presence of HIV in a patient.
REFERENCES:
patent: 4689320 (1987-08-01), Kaji
patent: 4806463 (1989-02-01), Goodchild et al.
patent: 4851330 (1989-07-01), Kohne
patent: 5023243 (1991-06-01), Tullis
patent: 5110802 (1992-05-01), Cantin et al.
patent: 5166195 (1992-11-01), Ecker
patent: 5190931 (1993-03-01), Inouye
patent: 5208149 (1993-05-01), Inouye
patent: 5264423 (1993-11-01), Cohen et al.
Rojanasakul 1996 Advances Drug Delivery Reviews 18, 115-131.
Fox 1994 Bio/Technology 12, 128.
Zhu et al. 1993 Science 261, 1179-1181.
Simons 1996 ASM News 62(4), 177-179.
Singleton et al. 1987 in: Dictionary of Microbiology and Molecular Biology (Second Edition) John Wiley and Sons, Chichester, GB, pp. 753-756.
Genesis Report-Rx, vol. 2, No. 4, Jun. 1993, Genesis Group Asssociates (Publ.).
Infectious Disease Weekly, 23 Oct. 1995, C. W. Henderson (Publ.).
H el en and Toulm e, "Specific Regulation Of Gene Expression by Antisense, Sence and Antigene Nucleic Acids," Chemica et Biophysica Acta 1049:99-125 (1990).
Uhlmann and Peyman, "Antisence Oligonucleotides: A New Therapeutic Principle," Chemical Reviews 90:544-584 (1990).
Majumdar et al., "Stepwise Mechanism of HIV Reverse Transcriptase: Primer Function of Phosphorothioate Oligodeoxynucleotide," Biochemistry 28:1340-1346 (1989).
Matsukura et al., "Regulation of Viral Expression of Human Immunodeficiency Virus In Vitro by an Antisense Phosphorothioate Oligodeoxynucleotide Against rev (art/trs) in Chronically Infected Cells," Proc. Natl. Acad. Sci. USA 86:4244-4248 (1989).
Zuker, "Computer Prediction of RNA Structure," Methods in Enzymology 180:262 (1989).
Green et al., "In Vitro Genetic Analysis of the Tetrahymena Self-Splicing Intron," Nature 347:406-408 (1990).
Ellington and Szostak, "In Vitro Selection of RNA Molcules That Bind Specific Ligands," Nature 346:818-822 (1990).
Bock et al., "Selection of Single-Stranded DNA Molecules That Bind and Inhibit Human Thrombin," Nature 355:564-566 (1992).
Burke and Berzal-Herranz, "In Vitro Selection and Evolution of RNA: Applications For Catalytic RNA, Molecular Recognitioin, and Drug Discovery," FASEB 7:106-112 (1993).
Nelson, "Detection of Acridinium Esters by Chemiluminescence," Nonisotopic DNA Probe Techniques, ed. Larry J. Kricka, (San Diego: Academic Press, Inc., 1992) pp. 275-310.
Schwartz et al., "Cloning and Functional Analysis of Multiply Spliced mRNA Species of Human Immuodeficiency Virus Type I," Journal of Virology 64:2519-2529 (1990).
Goodchild et al., "Inhibition of Human Immunodeficiency Virus Replication by Antisense Oligodeoxynucleotides," Proc. Natl. Acad. Sci. USA 85:5507-5511 (1988).
Britten and Davidson, "Hybridization Strategy," in Nucleic Acid Hybridization--A Practical Approach, ed. B.D. Hames and S.J. Higgins, (Washington D.C.: IRL Press 1985) pp. 3-15.
Tenover, "Diagnostic Deoxyribonucleic Acid Probes for Infectious Diseases," Clinical Microbiology Reviews 1:82-101 (1988).
Liebhaber et al., "Inhibition of mRNA Translation by Antisense Sequences," Gene Regulation: Biology of Antisense RNA and DNA, eds. R.P. Erickson and J.G. Izant, (New York: Raven Press, Ltd., 1992) 163-174.
Chatterjee et al., "Dual-Target Inhibition of HIV-1 in Vitro by Means of an Adeno-Associated Virus Antisense Vector," Science 258:1485-1488 (1992).
Lomelli et al., "Quantitative Assay Based on the Use of Replicatable Hybridization Probes," Clin. Chem. 35(9):1826-1831 (1989).
Ott and Eckstein, "Protection of Oligonucleotide Primers against Degradation by DNA Polymerase I," Biochemistry 26:8237-8241 (1987).
Sauvaigo et al., "Standardized Nested Polymerase Chain Reaction-Based Assay for Detection of Human Immunodeficiency Virus Type 1 DNA in Whole Blood Lysates," J. Chem. Microbiology 31(5):1066-1074 (1993).
Agrawal et al., "Inhibition of human immunodeficiency virus in early infected and chronically infected cells by antisense oligodeoxynucleotides and their phosphorothioate analogues," Proc. Natl. Acad. Sci. USA 86:7790-7794 (1989).
Ratner et al., "Complete nucleotide sequence of the AIDS virus, HTLV-III," Nature 313:277-284 (1985).
Morvan et al., "Comparative Evaluation of Seven Oligonucleotide Analogues as Potential Antisense Agents," J. Med. Chem. 36:280-287 (1993).
Stein and Cheng, "Antisense Oligonucleotide as Therapeutic Agents--Is the Bullet Really Magical?," Science 261:1004-1012 (1993).
Kinchington et al., "A comparison of gag, pol and rev antisense oligodeoxynucleotides as inhibitors of HIV-1," Antiviral Research 17:53-62 (1992).
Cantin and Woolf, "Antisense oligonucleotides as antiviral agents: prospects and problems," Trends in Microbiology 1:270-276 (1993).
Thierry and Dritschilo, "Intracellular availability of unmodified, phosphorothioated and liposomally encapsulated oligodeoxynucleotides for antisense activity," Nucleic Acids Research 20:5691-5698 (1992).
Lisziewicz et al., "Long-term treatment of human immunodeficiency virus-infected cells with antisense oligonucleotide phosphorothioates," Proc. Natl. Acad. Sci. USA 90:3860-3864 (1993).
Peterson Todd C.
Velarde, Jr. Jorge
Gen-Probe Incorporated
Low Christopher S. F.
LandOfFree
Oligonucleotides with activity against human immunodeficiency vi does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Oligonucleotides with activity against human immunodeficiency vi, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Oligonucleotides with activity against human immunodeficiency vi will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1386534