Oligonucleotides with activity against human immunodeficiency vi

Details Oligonucleotides with activity against human immunodeficiency vi Oligonucleotides with activity against human immunodeficiency vi

1997-06-02

1999-07-06

Elliott, George C.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

4353723, 536 245, C12N 508, C12N 510, C07H 2100

Patent

active

059197013

ABSTRACT:
The present invention features compounds and methods for inhibiting propagation of human immunodeficiency virus (HIV). Preferred HIV target sites are identified and oligonucleotides designed to hybridize to a target site are described. The preferred use of the oligonucleotides is as an anti-HIV agent to inhibit HIV propagation in a patient infected with HIV. Other uses of the present invention include detecting the presence of HIV by using the oligonucleotides as detection probes or amplification primers, and measuring the ability of an oligonucleotide to inhibit HIV propagation to evaluate its suitability as an anti-HIV agent for a phenotype of HIV or diagnose the presence of HIV in a patient.

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