Oligonucleotides to inhibit the expression of isoprenyl protein

Details Oligonucleotides to inhibit the expression of isoprenyl protein Oligonucleotides to inhibit the expression of isoprenyl protein

1995-06-23

1999-01-05

Elliott, George C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, C07H 2104

Patent

active

058564616

ABSTRACT:
The invention relates to oligonucleotides and their derivatives to inhibit the expression of isoprenyl protein transferases, therapeutic compositions containing such compounds and the use of such compositions of oligonucleotides for the treatment or therapy of diseases of the human or animal body induced by an abnormal and/or uncontrolled cellular proliferation.

REFERENCES:
patent: 4571421 (1986-02-01), Itakura
patent: 5348853 (1994-09-01), Wang et al.
patent: 5420245 (1995-05-01), Brown et al.
patent: 5585479 (1996-12-01), Hoke et al.
Prendergast et al. (1993) Negative growth selection against rodent fibroblasts targeted for genetic inhibition of farnesyl transferase. Cell Growth Differ. 4:707-713, Sep. 1993.
Uhlmann et al. (1990) Antisense oligonucleotides: a new therapeutic approach. Chem. Rev. 90:543-584, Jun. 1990.
Rojanasakul (1996) Antisense oligonucleotide therapeutics: drug delivery and targeting. Adv. Drug Del. Rev. 18:115-131, 1996.
Proceedings of the National Academy of Sciences of USA, vol. 87, Washington US, pp. 3042-3046 Jackson, J. et al. `Farnesol modification of Kirsten-ras exon 4B is essential for transformation`.

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