Oligonucleotides that inhibit production of .alpha.-tumor necros

Details Oligonucleotides that inhibit production of .alpha.-tumor necros Oligonucleotides that inhibit production of .alpha.-tumor necros

1994-11-18

1998-01-06

Rories, Charles C.P.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

435 6, 536 245, 536 231, 536 243, 536 2432, 536 2433, 536 2531, 536 2534, C12N 510, C07H 2102, C12Q 168, A61K 3170

Patent

active

057053898

ABSTRACT:
A sequence of anti-direction, anti-messenger RNA oligonucleotides of .alpha.-TNF characterized in that it possesses the structure of the formula ##STR1## wherein X is hydrogen, or a sequence of 1 to 17 oligonucleotides in free form, in alkylated form, in sulfurated form or in the form of a poly L-lysine derivative useful for stopping the production of .alpha.-TNF.

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Uhlmann et al, Chemical, Reviews, 90(4), 1990, 544-584.
Marmenout, et al, Eur. J. Biochemistry, 152, 515-522, 1985.
Melton, Proc. Natl. Acad. Sci, U.S.A, 82, 144-148, 1985.
Zon, Pharmaceutical Res., 5(9), pp. 539-549, 1988.

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