Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology
Patent
1998-02-20
2000-10-24
Schwartzman, Robert A.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Method of regulating cell metabolism or physiology
435 6, 435455, 4353201, 435325, 4352521, 43525233, 536 231, 536 241, 536 243, 536 245, C07H 2104, C12Q 168
Patent
active
061366021
ABSTRACT:
Disclosed are synthetic oligonucleotides complementary to a transcript of the marORAB operon which inhibit expression of a gene in the operon. Also disclosed are methods of reducing bacterial resistance to antibiotics, and pharmaceutical formulations containing marORAB-specific oligonucleotides of the invention.
REFERENCES:
patent: 5817793 (1998-10-01), Levy
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Branch. "A Good Antisense is Hard to Find" TIBS vol. 23: 45-50, Feb. 1998.
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Hoke, Glenn D. et al. (1991) "Effects of Phosphorothioate Capping on Antisense Oligonucleotide Stability, Hybridization and Antiviral Efficacy Versus Herpes Simplex Virus Infection", Nucleic Acids Research vol. 19, No. 20 pp. 5743-5748.
Metalev, Valeri et al. (1994) "Study of Antisense Oligonucleotide Phosphorothioates Containing Segments of Oligodeoxynucleotides and 2 O Methyloligoribonucleotides" Bioorganic & Medicinal Chemistry Letters vol. 4 No. 14 pp., 2929-2934.
White, D.G., et al. (1997) "Inhibition of the Multiple Antibiotic Resistance (mar) Operon in Escherichia Coli by Antisense DNA Analogs" Antimicrobial Agents and Chemotherapy vol. 41 pp. 2699-2704.
White, D.G., et al. (1997) "Inhibition of the Multiple Antibiotic Resistance (mar) Operon in Escherichia Coli by Antisense DNA Analogs" Abstracts of the General Meeting of the American Society for Microbiology Vo. 0 No. A-69 May 1997, Washington, D.C.
Hofe Eric von
Levy Stuart B.
Hybridon, Inc.
McGarry Sean
Schwartzman Robert A.
Trustees of Tufts College
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