Oligonucleotides possessing zwitterionic moieties

Details Oligonucleotides possessing zwitterionic moieties Oligonucleotides possessing zwitterionic moieties

1992-02-10

2000-01-25

Kunz, Gary L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 2, 536 245, 530300, A61K 31715, A61K 3804, C07H 2100, C07H 2104

Patent

active

060178957

ABSTRACT:
An oligonucleotide wherein at least one nucleotide unit includes a phosphonate moiety having the following structural formula: ##STR1## , wherein X is a zwitterionic moiety. Such oligonucleotides have improved cellular uptake capabilities and improved resistance against nuclease activity.

REFERENCES:
Cheng et al. Nucl. Acids Res. 11(3):659-669, 1983.

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