Oligonucleotides possessing a primary amino group in the termina

Details Oligonucleotides possessing a primary amino group in the termina Oligonucleotides possessing a primary amino group in the termina

1991-02-27

1992-06-02

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 24, 536 26, 536 27, 536 28, 536 29, C07H 19073, C07H 1916, C07H 1910, C07H 1920

Patent

active

051188007

ABSTRACT:
The invention consists of compounds and methods for the synthesis of oligonucleotides which contain one or more free aliphatic amino groups attached to the sugar moieties of the nucleoside subunits. The synthetic method is versatile and general, permitting amino groups to be selectively placed at any position on oligonucleotides of any composition or length which is attainable by current DNA synthetic methods. Fluorescent dyes or other detectable moieties may be covalently attached to the amino groups to yield the corresponding modified oligonucleotide.

REFERENCES:
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patent: 4401796 (1983-08-01), Itakura et al.
patent: 4415732 (1983-11-01), Caruthers et al.
patent: 4757141 (1988-07-01), Fung et al.
Chu et al., Nucl. Acids Res. 11:6513-6529, 1983.
Langer et al. Proc. Natl. Acad. Sci U.S.A. 78(11):6633-6637, 1981.
Draper et al. Biochemistry 19:1774-1781, 1980.

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