Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Reexamination Certificate
2006-04-11
2006-04-11
Myers, Carla J. (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
C435S006120, C435S091200, C536S023100, C536S023740, C536S024320, C536S024330
Reexamination Certificate
active
07026112
ABSTRACT:
The present invention is concerned with oligonucleotides that can be used as in the amplification and detection of Epstein Barr Virus (EBV) nucleic acid, in particular RNA-specific sequences. Furthermore a method for the diagnosis of EBV associated malignant and non-malignant diseases is provided. The oligonucleotides according to the present invention are specifically suited for the detection of EBV gene expression in circulating peripheral blood cells, in human (tumor) tissue samples and thin sections thereof using “in solution” amplification or “in situ” amplification techniques and in other biological samples potentially containing EBV-infected cells.
REFERENCES:
patent: 4965188 (1990-10-01), Mullis et al.
patent: 196 27 932 (1998-01-01), None
patent: 0 316 170 (1989-05-01), None
patent: 0 574 048 (1993-12-01), None
patent: 0 628 568 (1994-12-01), None
patent: 05 309000 (1993-11-01), None
patent: WO 93/07882 (1993-04-01), None
patent: WO 93/11267 (1993-06-01), None
patent: WO 93/23569 (1993-11-01), None
patent: WO 95/03415 (1995-02-01), None
patent: WO 97/32036 (1997-09-01), None
patent: WO 97/37669 (1997-10-01), None
patent: WO 98/04746 (1998-02-01), None
Myers, R.M. 1996. GenBank Accession No. G29936.
Myers, R.M.. 1996. GenBank Accession No. G34340.
NCBI, National Library of Medicine, NIH (Bethesda, MD, USA) Accession No. M80517, Apr. 1996.
NCBI Database, National Center for Biotechnology Information, National Library of Medicine, NIH (Bethesda, MD, USA) Accession No. I U21195, May 24, 1995.
Cheung et al., “Detection of Viral Sequences by Internally Calibrated Gene Amplification,” Biotechniques, vol. 14, No. 5, 1993, pp. 785-789.
Patent Abstracts of Japan, vol. 018, No. 114, 1994.
Kievits et al., “NASBA™ Isothermal Enzymatic in vitro Nucleic Acid Amplification Optimized for the Diagnosis of HIV-1 Infection,” Journal of Virological Methods, vol. 35, No. 3, 1991, pp. 273-286.
Database NCBI [online], “Human Herpesvirus 4 Genome,” Accession: NC001345, 1983 (abstract only).
Zhang et al., “Transcriptional Expression of the Viral Genome in the Epstein-Barr Virus-Induced Tamarin Lymphoma and the Corresponding Lymphoblastoid Tumour Lines,” Virus Research, vol. 26, 1992, pp. 153-166.
Tierney et al., “Epstein-Barr Virus Latency in Blood Mononuclear Cells: Analysis of Viral Gene Transcription During Primary Infection and in the Carrier State,” Journal of Virology, vol. 68, No. 11, 1994, pp. 7374-7385.
Brooks et al., “Epstein-Barr Virus Latent Gene Transcription in Nasopharyngeal Carcinoma Cells: Coexpression of EBNA1, LMP1 and LMP2 Transcripts,” Journal of Virology, vol. 66, No. 5, 1992, pp. 2689-2697.
Brink et al., Multiprimed cDNA Synthesis Followed by PCR is the Most Suitable Method for Epstein-Barr Virus Transcript Analysis in Small Lymphoma Biopsies, Mol. Cell. Probes, vol. 11, 1997, pp. 39-47.
Wei et al., “Expression and Tumorigenicity of the Epstein-Barr Virus BARF1 Gene in Human Louckes B-Lymphocyte Cell Line,” Cancer Research, vol. 54, 1994, pp. 1843-1848.
Touitou et al., “Transcriptional Analysis of the Epstein-Barr Virus Interleukin 10 Lomologue During the Lytic Cycle,” Journal of General Virology, vol. 77, 1996, pp. 1163-1168.
Labrecque et al., “Epstein-Barr Virus in Epithelial Cell Tumors: A Breast Cancer Study,” Cancer Research, vol. 55, 1995, pp. 39-45.
Brink et al., “Nucleic Acid Sequence-Based Amplification, A New Method for Analysis of Spliced and Unspliced Epstein-Barr Virus Latent Transcripts, and its Comparison with Reverse Transcriptase,” Journal of Clinical Microbiology, vol. 36, No. 11, 1998, pp. 3164-3169.
Hayes et al., “Expression of Epstein-Barr Virus (EBV) Transcripts Encoding Homologues to Important Human Proteins in Diverse EBV Associated Diseases,” Molecular Pathology, vol. 52, No. 2, 1999, pp. 97-103.
Middeldorp Jaap Michiel
van den Brule Adrianus Johannes Christiaan
Vervoort Marcel Bartolina Hendrikus Johannes
Akzo Nobel N.V.
Myers Carla J.
Myers Bigel Sibley & Sajovec P.A.
LandOfFree
Oligonucleotides for the amplification and detection of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Oligonucleotides for the amplification and detection of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Oligonucleotides for the amplification and detection of... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3546112