Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2011-03-08
2011-03-08
Minnifield, N. M. (Department: 1645)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C536S023100, C424S278100
Reexamination Certificate
active
07902161
ABSTRACT:
Disclosed are oligonucleotides for manipulating an immune reaction. The oligonucleotides of the present invention may be useful to stimulate the immune function, to treat the immune-related diseases and the atopic dermatitis, or to protect the normal immune cells.
REFERENCES:
patent: 6207646 (2001-03-01), Krieg et al.
patent: 6406705 (2002-06-01), Davis et al.
patent: 2004/0029129 (2004-02-01), Wang et al.
patent: 9840100 (1998-09-01), None
Ballas et al. The Journal of Immunology, 2001, 167:4878-4886.
Akdis, et al., “Immune regulation in atopic dermatitis.” Curr Opin Immunol. Dec. 2000;12(6):641-6.
Kwon, et al., “NF-kappaB-dependent regulation of tumor necrosis factor-alpha gene expression by CpG-oligodeoxynucleotides.” Biochem Biophys Res Commun. Nov. 7, 2003;311(1):129-38.
Deng, et al., “The features of arthritis induced by CpG motifs in bacterial DNA.” Arthritis Rheum. Feb. 2000;43 (2):356-64.
Tanaka, et al., “An antisense oligonucleotide complementary to a sequence in I gamma 2b increases gamma 2b germline transcripts, stimulates B cell DNA synthesis, and inhibits immunoglobulin secretion” J Exp Med. Feb. 1, 1992;175(2):597-607.
Davis, et al., “CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen.” J Immunol. Jan. 15, 1998;160(2):870-6.
Rudikoff, et al., “Atopic dermatitis.” Lancet. Jun. 6, 1998;351(9117):1715-21.
Imokawa, et al., “Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin?” J Invest Dermatol. Apr. 1991;96(4):523-6.
Ashwell, et al., “Effect of gamma radiation on resting B lymphocytes. I. Oxygen-dependent damage to the plasma membrane results in increased permeability and cell enlargement.” J Immunol. May 15, 1986;136(10):3649-56.
Prosser “Survival of human T and B lymphocytes after X-irradiation.” Int J Radiat Biol Relat Stud Phys Chem Med. Nov. 1976;30(5):459-65.
Kubota, et al., “Radiation-induced apoptosis in peritoneal resident macrophages of C3H mice” J Radiat Res (Tokyo). Jun. 2004;45(2):205-11.
Krieg, A M, “CpG motifd in bacterial DNA and their immune effects” Annu. Rev. Immunol, 2002, vol. 20:709-742.
Krieg, et al, “CpG motifs in bacterial DNA trigger direct B-cell activation” 1995, nature vol. 374, p. 546-549.
Uhlmann, et al., “Recent advances in the development of immunostimulatory oligonucleotides” Mar. 2003, Current Opinion in Drug Discovery & Development Mar. 2003, vol. 6, No. 2, pp. 204-217.
Krieg, et al., “Mechanism of Action of CpG DNA” Jan. 1, 2000, Current Topics in Microbiology and Immunology, Springer, Berlin, DE, vol. 247, 1, pp. 1-21.
Ballas, et al. “Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA” J Immunol. Sep. 1, 1996;157(5):1840-5.
Klinman, et al. “CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma” Proc Natl Acad Sci U S A. Apr. 2, 1996;93(7):2879-83.
Kim Doo-Sik
Kim Tae-Yoon
Kwon Hyung-Joo
Jones S.C. Casimir
Kim Tae-Yoon
Kwon Hyung-Joo
Minnifield N. M.
Ogunbiyi Oluwatosin
LandOfFree
Oligonucleotides derived from mycobacterium for... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Oligonucleotides derived from mycobacterium for..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Oligonucleotides derived from mycobacterium for... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2684105