Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2006-04-04
2006-04-04
Wang, Andrew (Department: 1635)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
Reexamination Certificate
active
07022832
ABSTRACT:
Oligonucleotides capable of modifying or inhibiting in vivo or in vitro expression of a target gene wherein the oligonucleotide has an antisense sequence, at least one secondary structure, and optionally a supplementary nucleotide sequence located at one and/or both ends of the antisense sequence and wherein the secondary structure disintegrates upon attachment of the oligonucleotide to a target nucleic acid; a pharmaceutical composition containing such an oligonucleotide as an active ingredient; and a method of treatment using such an oligonucleotide.
REFERENCES:
patent: WO/94/01550 (1994-01-01), None
patent: WO 94/12633 (1994-06-01), None
patent: WO 94/23026 (1994-10-01), None
patent: WO 95/29241 (1995-11-01), None
Wang et al. Antisense and Nucleic Acid Drug Delivery, 2003, vol. 13, p. 169-189.
Flanagan et al., Nature Biotechnology. vol. 17 p. 48-52 Jan. 1999.
Opalinska et al. Nature Review, 2002, vol. 1, p. 503-514.
Agrawal et al. Molecular Medicine Today,2000, vol. 6, p 72-81.
Green et al. J. Am Coll. Surg., 2000, vol. 191, p 93-105.
Jen et al. Stem Cells 2000, vol. 18, p 307-319.
Crooke, Antisense Research and Application, Chapter 1, Springer-Verlag, New York, 1998.
Branch, TIBS, 1998, vol. 23, p 45-50.
Sokol, D. L. et al, “Real time detection of DNA-RNA hybridization in living cells”, Proc. Natl. Acad. Sci. USA, Sep. 9, 1998, pp. 11538-11543.
Abe, T. et al., “Specific inhibition of influenza virus RNA polymerase and nucleoprotein gene expression by circular dumbdell RNA/DNA chimeric oligonucleotides containing antisense phosphodiester oligonucleotides,” Febs Lett 425(1), Mar. 20, 1998, pp. 91-96.
Barker RH Jr. et al, Plasmodium falciparum: Effect of Chemical Structure on Efficacy and Specificity of Antisense Oligonucleotides against Malaria in Vitro, Experimental Parasitology 88, Jan. 1998, pp. 51-59.
Jolles, B. et al, Opening of the extraordinaril,y stable mini-hairpin d(GCGAAGC), Nucleic Acids Research, vol. 25. No. 22, Nov. 15, 1997, pp. 4608-4613.
Tanaka, Kazuhiro et al., EWS-Flil Antisense Oligodeoxynucleotide Inhibits Proliferation of Human Ewings's Sarcoma and Primitive Neurectodermal Tumor Cells, Journal of Clinical Investigation, vol. 99, No. 2, 1997, pp. 239-247.
Gottikh, M.B. et al, “α-β Chimeric Oligonucleotides Form a New Stable “Snail-like”Structure,”, J. Am. Chem. Soc., 1996, 118, pp. 2126-2130.
Tang, J. et al, Self-stabilized antisense oligodexynucleotide phosphorothioates: properties and anti-HIV activity, Nucl. Acids Research, vol. 21, No. 11, 1993, pp. 2729-2735.
Gottikh Marina
Helin Valerie
Maksimenko Andrei
Malvy Calude
Bioalliance Pharma (S.A.)
Centre National de la Recherche Scientifique "CNRS"
DLA Piper Rudnick Gray Cary US LLP
Vivlemore Tracy
Wang Andrew
LandOfFree
Oligonucleotides containing an antisense sequence stabilized... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Oligonucleotides containing an antisense sequence stabilized..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Oligonucleotides containing an antisense sequence stabilized... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3537850