Oligonucleotides comprising a modified or non-natural...

Details Oligonucleotides comprising a modified or non-natural... Oligonucleotides comprising a modified or non-natural...

2005-07-21

2009-08-25

Riley, Jezia (Department: 1637)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S024300, C536S024330, C435S006120

Reexamination Certificate

active

07579451

ABSTRACT:
One aspect of the present invention relates to a double-stranded oligonucleotide comprising at least one non-natural nucleobase. In certain embodiments, the non-natural nucleobase is difluorotolyl, nitroindolyl, nitropyrrolyl, or nitroimidazolyl. In a preferred embodiment, the non-natural nucleobase is difluorotolyl. In certain embodiments, only one of the two oligonucleotide strands comprising the double-stranded oligonucleotide contains a non-natural nucleobase. In certain embodiments, both of the oligonucleotide strands comprising the double-stranded oligonucleotide independently contain a non-natural nucleobase. In certain embodiments, the oligonucleotide strands comprise at least one modified sugar moiety. Another aspect of the present invention relates to a single-stranded oligonucleotide comprising at least one non-natural nucleobase. In a preferred embodiment, the non-natural nucleobase is difluorotolyl. In certain embodiments, the ribose sugar moiety that occurs naturally in nucleosides is replaced with a hexose sugar, polycyclic heteroalkyl ring, or cyclohexenyl group. In certain embodiments, at least one phosphate linkage in the oligonucleotide has been replaced with a phosphorothioate linkage.

REFERENCES:
patent: 5677124 (1997-10-01), DuBois et al.
patent: 5861947 (1999-01-01), Neumann et al.
patent: 5919625 (1999-07-01), DuBois et al.
patent: 5939262 (1999-08-01), Pasloske et al.
patent: 5952490 (1999-09-01), Hanek et al.
patent: 6057134 (2000-05-01), Lader et al.
patent: 6232103 (2001-05-01), Short
patent: 6239159 (2001-05-01), Brown et al.
patent: 6399334 (2002-06-01), Li et al.
patent: 6593464 (2003-07-01), Gebeyehu et al.
patent: 6610490 (2003-08-01), Schuster et al.
patent: 6620926 (2003-09-01), Sproat
patent: 6623962 (2003-09-01), Akhtar et al.
patent: 6649751 (2003-11-01), Usman et al.
patent: 6673611 (2004-01-01), Thompson et al.
patent: 6673918 (2004-01-01), Bellon et al.
patent: 6686463 (2004-02-01), Beigelman et al.
patent: 6797815 (2004-09-01), Matulic-Adamic et al.
patent: 6815205 (2004-11-01), Lin et al.
patent: 6818447 (2004-11-01), Pavco et al.
patent: 6818759 (2004-11-01), Beigelman et al.
patent: 6830902 (2004-12-01), Astatke et al.
patent: 6849726 (2005-02-01), Usman et al.
patent: 6933121 (2005-08-01), Schuster et al.
patent: 6972330 (2005-12-01), Beigelman et al.
patent: 6977295 (2005-12-01), Belotserkovskii et al.
patent: 7399586 (2008-07-01), Klinghoffer et al.
patent: 2002/0025526 (2002-02-01), Schuster et al.
patent: 2002/0034750 (2002-03-01), Short
patent: 2002/0086356 (2002-07-01), Tuschl et al.
patent: 2002/0132346 (2002-09-01), Cibelli
patent: 2002/0143166 (2002-10-01), Pires et al.
patent: 2002/0162126 (2002-10-01), Beach et al.
patent: 2002/0182590 (2002-12-01), Strange et al.
patent: 2003/0084471 (2003-05-01), Beach et al.
patent: 2003/0104985 (2003-06-01), Matulic-Adamic et al.
patent: 2003/0108923 (2003-06-01), Tuschl et al.
patent: 2003/0143732 (2003-07-01), Fosnaugh et al.
patent: 2003/0148507 (2003-08-01), Fosnaugh et al.
patent: 2003/0157030 (2003-08-01), Davis et al.
patent: 2003/0167490 (2003-09-01), Hunter et al.
patent: 2003/0170711 (2003-09-01), Brown et al.
patent: 2003/0170891 (2003-09-01), McSwiggen
patent: 2003/0171315 (2003-09-01), Brown et al.
patent: 2003/0175950 (2003-09-01), McSwiggen
patent: 2003/0190635 (2003-10-01), McSwiggen
patent: 2003/0190661 (2003-10-01), Gruber et al.
patent: 2003/0204077 (2003-10-01), Simms
patent: 2003/0206887 (2003-11-01), Morrissey et al.
patent: 2004/0009522 (2004-01-01), Wu
patent: 2004/0009946 (2004-01-01), Lewis et al.
patent: 2004/0014113 (2004-01-01), Yang et al.
patent: 2004/0018181 (2004-01-01), Kufe et al.
patent: 2004/0018999 (2004-01-01), Beach et al.
patent: 2004/0019001 (2004-01-01), McSwiggen
patent: 2004/0044190 (2004-03-01), Sproat
patent: 2004/0058886 (2004-03-01), Scaringe
patent: 2004/0063654 (2004-04-01), Davis et al.
patent: 2004/0077574 (2004-04-01), Klinghoffer et al.
patent: 2004/0086884 (2004-05-01), Beach et al.
patent: 2004/0121353 (2004-06-01), Lewis et al.
patent: 2004/0138163 (2004-07-01), McSwiggen et al.
patent: 2004/0142895 (2004-07-01), Lockridge et al.
patent: 2004/0147735 (2004-07-01), Laurent et al.
patent: 2004/0161777 (2004-08-01), Baker et al.
patent: 2004/0191905 (2004-09-01), Stevenson et al.
patent: 2004/0192626 (2004-09-01), McSwiggen et al.
patent: 2004/0192629 (2004-09-01), Xu et al.
patent: 2004/0198640 (2004-10-01), Leake et al.
patent: 2004/0198682 (2004-10-01), McSwiggen et al.
patent: 2004/0203024 (2004-10-01), Baker et al.
patent: 2004/0203145 (2004-10-01), Zamore et al.
patent: 2004/0204420 (2004-10-01), Rana
patent: 2004/0209831 (2004-10-01), McSwiggen et al.
patent: 2004/0209832 (2004-10-01), McSwiggen et al.
patent: 2004/0214198 (2004-10-01), Rana
patent: 2004/0219671 (2004-11-01), McSwiggen et al.
patent: 2004/0220128 (2004-11-01), Pavco et al.
patent: 2004/0224405 (2004-11-01), Leake et al.
patent: 2004/0229266 (2004-11-01), Tuschl et al.
patent: 2004/0234504 (2004-11-01), Verma et al.
patent: 2004/0235775 (2004-11-01), Kung et al.
patent: 2004/0247178 (2004-12-01), Reese
patent: 2004/0259247 (2004-12-01), Tuschl et al.
patent: 2004/0259248 (2004-12-01), Tuschl et al.
patent: 2004/0266707 (2004-12-01), Leake et al.
patent: 2005/0004063 (2005-01-01), Kung et al.
patent: 2005/0014172 (2005-01-01), Richards et al.
patent: 2005/0020525 (2005-01-01), McSwiggen et al.
patent: 2005/0026278 (2005-02-01), Tuschl et al.
patent: 2005/0032733 (2005-02-01), McSwiggen et al.
patent: 2005/0042646 (2005-02-01), Davidson et al.
patent: 2005/0048529 (2005-03-01), McSwiggen
patent: 2005/0054596 (2005-03-01), McSwiggen et al.
patent: 2005/0054598 (2005-03-01), McSwiggen
patent: 2005/0054847 (2005-03-01), Madden et al.
patent: 2005/0059817 (2005-03-01), Beigelman et al.
patent: 2005/0070497 (2005-03-01), McSwiggen et al.
patent: 2005/0075304 (2005-04-01), McSwiggen et al.
patent: 2005/0079610 (2005-04-01), Polisky et al.
patent: 2005/0096284 (2005-05-01), McSwiggen
patent: 2005/0106726 (2005-05-01), McSwiggen et al.
patent: 2005/0119211 (2005-06-01), Chowrira et al.
patent: 2005/0119212 (2005-06-01), Haeberli et al.
patent: 2005/0124566 (2005-06-01), Robin et al.
patent: 2005/0124567 (2005-06-01), McSwiggen et al.
patent: 2005/0124568 (2005-06-01), Usman et al.
patent: 2005/0124569 (2005-06-01), Guerciolini et al.
patent: 2005/0130181 (2005-06-01), McSwiggen
patent: 2005/0136436 (2005-06-01), McSwiggen et al.
patent: 2005/0137153 (2005-06-01), McSwiggen et al.
patent: 2005/0137155 (2005-06-01), McSwiggen et al.
patent: 2005/0142578 (2005-06-01), Usman et al.
patent: 2005/0143333 (2005-06-01), Richards et al.
patent: 2005/0148530 (2005-07-01), McSwiggen et al.
patent: 2005/0153914 (2005-07-01), McSwiggen et al.
patent: 2005/0153915 (2005-07-01), Usman et al.
patent: 2005/0153916 (2005-07-01), McSwiggen et al.
patent: 2005/0158735 (2005-07-01), McSwiggen et al.
patent: 2005/0159376 (2005-07-01), McSwiggen et al.
patent: 2005/0159378 (2005-07-01), McSwiggen et al.
patent: 2005/0159379 (2005-07-01), McSwiggen et al.
patent: 2005/0159380 (2005-07-01), Guerciolini et al.
patent: 2005/0159381 (2005-07-01), McSwiggen et al.
patent: 2005/0159382 (2005-07-01), McSwiggen et al.
patent: 2005/0164224 (2005-07-01), McSwiggen et al.
patent: 2005/0164966 (2005-07-01), McSwiggen et al.
patent: 2005/0164967 (2005-07-01), McSwiggen et al.
patent: 2005/0164968 (2005-07-01), McSwiggen et al.
patent: 2005/0170371 (2005-08-01), McSwiggen et al.
patent: 2005/0171039 (2005-08-01), McSwiggen et al.
patent: 2005/0171040 (2005-08-01), Polisky et al.
patent: 2005/0176018 (2005-08-01), Thompson et al.
patent: 2005/0176024 (2005-08-01), McSwiggen et al.
patent: 2005/0176025 (2005-08-01), McSwiggen et al.
patent: 2005/0176045 (2005-08-01), Fedorov et al.
patent: 2005/0176663 (2005-08-01), McSwiggen et al.
patent: 2005/0176664 (2005-08-01), Richards et al.
patent: 2005/0176665 (2005-08-01), McSwiggen
patent: 2005/0176666 (2005-08-01), Richards et al.
patent: 2005/0182006 (2005-08-01), McSwiggen et al.
patent: 2005/0182007 (2005-08-01), McSwiggen et al.
patent: 2005/0182008 (2005

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