Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving fixed or stabilized – nonliving microorganism,...
Patent
1996-02-28
1998-06-09
Kunz, Gary L.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving fixed or stabilized, nonliving microorganism,...
536 221, 536 245, 536 243, 536 2431, C07H 2102, C07H 2104, A61K 3170
Patent
active
057632081
ABSTRACT:
Oligonucleotides that are capable of passive diffusion across cell membranes are disclosed. These oligonucleotides contain at least two nucleotide residues and show a log distribution coefficient in octanol:water of about 0.0-2.5 and a solubility in water of at least 0.001 .mu.g/mL. In preferred embodiments, either at least 80% of the internucleotide linkages are non-ionic, or at least 80% of the bases contain lipophilic hydrocarbyl substitutions, or a combination of these sums to 80%. These oligonucleotides may be conjugated to label and used to visualize cells.
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Bischofberger Norbert
Buhr Chris
Kent Ken
Lin Kuei-Ying
Wagner Rick
Gilead Sciences, Inc.
Kunz Gary L.
Muenchau Daryl D.
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