Oligonucleotides and related compounds

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Structurally-modified antibody – immunoglobulin – or fragment...

Reexamination Certificate

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C536S023100

Reexamination Certificate

active

07846436

ABSTRACT:
The present invention relates generally to oligonucleotides and more specifically to oligonucleotides which have a sequence including at least two CpG dinucleotides and a prodrug of an antimetabolite. The prodrug can be part of a CpG dinucleotide or may be attached elsewhere on the oligonucleotide.

REFERENCES:
Weiner J. Leukocyte Biology, 2000; 68: 455-463.
Krieg et al (Nature 1995; 374: 546-549).
Belles et al (J. Immunology 2001; 167: 4878).
Agrawal et al (Trends in Molecular Medicine, 2002, 8/3:114-120).
Donnelly et al (Nature Medicine, 2003, 9/11:1354-1356).
DeGruijl et al, Nature Medicine, 1999, 5/10:1124-1125.
Bitton R. J. (Current Opinion in Molecular Therapeutics, 2004, 6/1:17-25).
Freshney (Culture of Animal Cells, A Manual of Basic Technique, Alan R. Liss, Inc., 1983, New York, p. 4).
Dermer (Bio/Technology, 1994, 12:320).

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