Oligonucleotides

Details Oligonucleotides Oligonucleotides

2000-03-06

2003-06-24

Zitomer, Stephanie W. (Department: 1655)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S288300, C536S024100

Reexamination Certificate

active

06582908

ABSTRACT:

FIELD OF THE INVENTION
The present invention provides nucleic acid sequences useful for analyzing molecular interactions of biological interest. The invention therefore relates to diverse fields impacted by the nature of molecular interaction, including chemistry, biology, medicine, and medical diagnostics.
SUMMARY OF THE INVENTION
The invention provides nucleic acid sequences for a variety of analyses, including, for example, gene expression analysis. For example, in one embodiment the invention comprises 1 or more, 10 or more, 1×10
3
or more, 1×10
6
or more, or 1×10
12
or more nucleic acid sequences containing 10 or more nucleotides for a variety of uses, including, but not limited to, as a probe, as a primer for PCR or as a ligand. In a further embodiment, the invention comprises 10 or more, 1×10
2
or more, 1×10
3
or more, 1×10
4
or more, 1×10
6
or more, 1×10
8
or more, 1×10
10
or more, 1×10
11
or more, 1×10
12
or more, or 1×10
14
or more, nucleic probes containing 10 or more nucleotides attached to a solid support to form an array. In a further embodiment, the invention comprises the use of the above array to: monitor gene expression levels by hybridization of the array to a DNA library; monitor gene expression levels by hybridization to an mRNA-protein fusion compound; identify polymorphisms; identify biallelic markers; produce genetic maps; analyze genetic variation; comparatively analyze gene expression between different species; analyze gene knockouts; hybridize tag-labeled compounds; or perform a wide variety of other analyses.


REFERENCES:
patent: 5569588 (1996-10-01), Ashby et al.
patent: 5700637 (1997-12-01), Southern
patent: 5795724 (1998-08-01), Hillman et al.
patent: 6344316 (2002-02-01), Lockhart et al.

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