Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1997-05-28
1999-11-09
Marschel, Ardin H.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435395, 536 221, 536 2532, 536 254, 536 255, 204606, C12Q 168, C07H 2102, C07H 2100
Patent
active
059811854
ABSTRACT:
A solid support based hybridization assay is provided which allows for the systematic and reproducible analysis of repeat and tandem repeat oligonucleotide sequences of DNA and RNA by hybridization to a reverse dot blot array comprising strings of such repeats complementary to those found in particular nucleic acid targets (e.g., analyte PCR product). An addressable library (i.e., an indexed set) of complementary repeats is synthesized on a suitable support. Preferably, the support comprises a low fluorescent background support, thereby facilitating the use of non-radioisotopic modes of detection (such as fluorescence or chemiluminescence); particularly suitable in this regard is an aminated polypropylene support or similar material. Preferred arrays permit screening of DNA and RNA samples for complete sets of particular types of nucleotide repeat sequences (e.g., all nucleotide doublet or triplet repeats).
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Armour, J.A.L. et al., Human Molecular Genetics, 1994, vol. 3, No. 4 599-605.
Karagyozov, L. et al., Nucleic Acids Research, 1993, vol. 21, No. 16 3911-3912.
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Caskey Charles Thomas
Coassin Peter J.
Matson Robert S.
Rampal Jang B.
Beckman Coulter Inc.
Kivinski Margaret A.
Marschel Ardin H.
May William H.
Tung Joyce
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