Oligonucleotide probes to L-AP4 sensitive glutamate receptor seq

Details Oligonucleotide probes to L-AP4 sensitive glutamate receptor seq Oligonucleotide probes to L-AP4 sensitive glutamate receptor seq

1995-05-30

1998-11-03

Marschel, Ardin H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 536 243, 536 2431, C12Q 168, C07H 2102, C07H 2104

Patent

active

058310479

ABSTRACT:
Metabotropic receptor mGluR7 is identified and sequenced. The mGluR7 receptor subfamily mediates inhibition of transmitter release at selected glutamatergic synapses. The receptors, mGluR7-specific peptides and antibodies thereto are used to identify agonists and antagonists of G protein coupled glutamate receptor mediated neuronal transmitter release, as well as in methods of diagnosis and therapy.

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patent: 5498696 (1996-03-01), Briggs et al.
Puranam et al. "Chromosomal Localization of Gene for Human Glutamate Receptor Subunit-7" Somatic Cell and Molecular Genetics, vol. 19, No. 6, pp. 581-588, Nov. 1993.
New England Biolabs Catalog, Beverly, MA, USA p. 62, 1986.
Gregor et al., "Chromosomal Localization of Glutamate Receptor Genes: Relationship to Familial Amyotrophic Lateral Sclerosis and Other Neurological Disorders of Mice and Humans", Proc. Natl. Acad. Sci. USA 90:3053-3057 (Apr., 1993).

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