Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Patent
1995-03-07
1996-08-27
Horlick, Kenneth R.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
435 6, 435810, 536 2431, 536 2433, C12P 1934, C07H 2104
Patent
active
055500390
ABSTRACT:
The present invention provides primers for the polymerase chain reaction amplification of a nucleic acid sequence encompassing the polymorphic regions of the second, third, and fourth exons of the HLA Class I B gene (HLA-B). The polymorphic regions of the second, third, and fourth exons of the HLA-B gene contain sufficient variability so that each allele is uniquely identified by the nucleic acid sequence within these regions. The primers and amplification methods of the present invention enable genotyping at the HLA-B locus using samples from a variety of sources and for detecting allelic variants not distinguishable by serological methods. The HLA-B DNA genotyping can be used for tissue typing, determining individual identity, and identifying disease susceptible individuals.
REFERENCES:
patent: 4683195 (1987-07-01), Mullis et al.
patent: 5424184 (1995-06-01), Santamaria et al.
Yoshida et al., Human Immunol. 34, 257-266 (1992).
Guttridge et al., Tissue Antigens 45, 213-215 (Mar. 1995).
Sadler et al., Tissue Antigens 44,148-154 (Sept. 1994).
Olerup et al., Tissue Antigens 43, 253-256 (Apr. 1994).
Guttridge et al., Tissue Antigens 44, 43-46 (Jul. 1994).
Bunce et al., Tissue Antigens 45, 81-90 (Feb. 1995).
Dominguez et al., Immunogentics 36, 277-282 (1992).
Yao et al., Human Immunol. 42, 54-60 (1995).
Andrien et al., Tissue Antigens 42, 480-487 (1993).
Baxter-Lowe et al., Aug. 1989, "HLA Gene Amplification and Hybridization Analysis of Polymorphism" J. Clin. Invest. 84:613-618.
Bjorkman and Parham, 1990, "Structure, Function, and Diversity of Class I Major Histocompatibility Complex Molecules" Annu. Rev. Biochem. 59:253-288.
Ennis et al., Apr. 1990, "Rapid Cloning of HLA-A, B cDNA by Using the Polymerase Chain Reaction: Frequency and Nature of Errors Produced in Amplification" 87:2833-2837.
Hill et al., Mar. 1991, "HLA Class I Typing by PCR: HLA-B27 and an African B27 Subtype" Lancet 337:640-642.
Lawlor et al., Feb., 1991, "Ancient HLA Genes From 7,500--Year Old Archaeological Remains" Nature 249:785-788.
Zemmour and Parham, 1991, "HLA Class I Nucleotide Sequences, 1991" Immunogenetics 33:310-320.
Yoshida et al., 1992, "Polymerase-Chain -Reaction-Based Analysis of Polymorphism in the HLA-B Gene" Human Immunology 34:257-266.
Bodmer et al., 1994, "Nomenclature for Factors for the HLA System,1994" Tissue Antigens 44:1-18.
Bugawan et al., 1994, "A Method for Typing Polymorphism at the HLA-A Locus Using PCR Amplification and Immobilized Oligonucleotides Probes" Tissue Antigens 44:137-147.
Guttridge et al., 1994, "Identification of HLA-B35, B53,B18,B5, B78, and B17 Alleles by the Polymerase Chain Reaction Using Sequence-Specific Primers (PCR-SSP)" Tissue Antigens 44:43-46.
Hildebrand et al., 1994, "HLA-B15: A Widespread and Diverse Family of HLA-B Alleles" Tissue Antigens 43:209-218.
Olerup, 1994, "HLA-B27 Typing by a Group-Specific PCR Amplification" Tissue Antigens 43: 253-256.
Gould George M.
Hoffmann-La Roche Inc.
Horlick Kenneth R.
Petry Douglas A.
Sias Stacey R.
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