Oligonucleotide-polyamide conjugates and methods of production a

Details Oligonucleotide-polyamide conjugates and methods of production a Oligonucleotide-polyamide conjugates and methods of production a

1995-01-03

1996-06-11

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435810, 436501, 536 221, 536 231, 536 241, 536 243, 536 2431, 536 2432, 536 2433, 536 253, 935 77, 935 78, 935 88, C12Q 168, C07H 1910, G01N 3350

Patent

active

055254659

ABSTRACT:
Oligonucleotide-polyamide conjugates of the formula X--L--Y, where X is a polyamide, Y is an oligonucleotide, and L is a linker which forms a covalent bond with the amino-terminus of the polyamide X and the 3' phosphate group of the oligonucleotide Y. Conjugates may be synthesized by assembling a polyamide on a solid support matrix, adding a suitable linker molecule, followed by synthesis of the oligonucleotide. Methods for detecting specific polynucleotides with oligonucleotide-polyamide conjugates are also described.

REFERENCES:
patent: 4828979 (1989-05-01), Klevan et al.
Lehninger, Biochemistry, "Molecular Basis of Cell Structure and Function", 2d Ed., pp. 932-936, Worth Publishers, Inc. (1978).
Chu, B. C. F. et al., "Derivation of unprotected polynucleotide" Nucleic Acids Research, 11 (18), issued 1983 (IRL Press Ltd., Oxford, England) pp. 6513-6529.
Biochemistry (1970) A. L. Lehninger (Worth Publishers, New York, NY) p. 695.

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