Oligonucleotide-polyamide conjugates

Details Oligonucleotide-polyamide conjugates Oligonucleotide-polyamide conjugates

1996-02-09

1997-10-14

Marschel, Ardin H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 435810, 436501, 536 231, 536 241, 935 78, C07H 2100

Patent

active

056774400

ABSTRACT:
Conjugates of the type Z--X--L are described wherein Z is a solid phase matrix, X is a single amino acid or a polyamide of two or more amino acid residues, and L is a linker that is capable of linking between the amino terminus of X and a 3'-phosphate of a nucleotide. Conjugates may also be synthesized by assembling a polyamide on a solid support matrix, adding a suitable linker molecule, followed by synthesis of an oligonucleotide thereon. Methods for detecting specific polynucleotides with oligonucleotide-polyamide conjugates are also described.

REFERENCES:
patent: 4828979 (1989-05-01), Klevan et al.
patent: 5118605 (1992-06-01), Urdea
Lehninger, Biochemistry, "Molecular Basis of Cell Structure and Function", 2d Ed., pp. 932-936, Worth Publishers, Inc. (1978).
Lehninger Biochemistry, "The Molecular Basis of Cell Structure and Function", pp. 695, Worth Publishers, Inc. (1970).
Chu, B.C.F. et al., Nucleic Acids Res. 11(18) pp. 6513-6529 "Derivatization of Unprotected Polynucleotides" (1983).

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