Oligonucleotide phosphate esters

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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536 243, 536 245, 536 251, 435 6, C07H 2100, C07H 2102, C07H 2104

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active

060158867

ABSTRACT:
This invention relates to synthetic oligonucleotides that are useful for antisense based therapeutic applications. The synthetic oligonucleotides of this invention have modifications in the sugar phosphate backbone for improved antisense properties.

REFERENCES:
patent: 5214135 (1993-05-01), Srivastava et al.
patent: 5525719 (1996-06-01), Srivastava et al.
patent: 5750669 (1998-05-01), Rosch et al.
Hirao et al., "Synthesis and Properties of an Initiation Codon Analog Consisting of 2'-O-methyl Nucleosides," Nucleosides Nucleotides, 9(8), 1113-1122 (1990); Chem. Abstr., 114(21), p. 873, Abstr. No. 207676t (May 27, 1991).
Kierzek et al.(I), "Some Steric Aspects of Synthesis of Oligoribonucleotides by Phosphoamidite Approach on Solid Support," Bull. Pol. Acad. Sci., Chem., 35(11-12), 507-516 (1988); Chem. Abstr., 110(7), p. 126, Abstr. No. 57990s (Feb. 13, 1989); both Abstract and original publication supplied.
Leonard et al., "A Convenient Preparation of Protected 2'-O-Methylguanosine," Nucleosides Nucleotides, 11(6), 1201-1204 (1992); Chem. Abstr., 117(17), p. 895, Abstr. No. 171915r (Oct. 26, 1992).
Yamana et al., "Synthesis and Properties of Oligonucleotides Bearing a Pendant Pyrene Group," in the Thirteenth Symposium on Nucleic Acids Chemistry, Nucleic Acids Symposium Series, No. 16, IRL Press, Osaka, Japan, Nov. 6-8,.1985, pp. 169-172.
Wagner et al., "A Simple Procedure for the Preparation of Protected 2'-O-Methyl or 2'-O-Ethyl Ribonucleoside-3'-O-phosphoramidites," Nucleic Acids Res., 19(21), 5965-5971 (1991).
Venijaminova et al., "Oligo(2'-O-Methylribonucleotides) and Their Derivatives. I. Automatic H-Phosphonate Synthesis of the Oligo(2'-O-Methylribonucleotides) Via H-Phosphonates," Bioorg. Khim., 16(5), 635-642 (Aug. 4, 1989); English abstract, Russian text.
Inoue et al.(I), "Synthesis and Hybridization Studies on Two Complementary Nona(2'-O-Methyl)ribonucleotides," Nucleic Acids Res., 15(15), 6131-6148 (1987).
Shibahara et al.(II), "Site-directed Cleavage of RNA," Nucleic Acids Res., 15(11), 4403-4415 (1987).
Alexandrova et al.(I), "Synthesis of Cytidylyl-(3'-5')-2'-O(and 3'-O)-Methyladenosine 3'-O(and 2'-O)-N-Formyl-L-methionyl Derivatives," Coll. Czech. Chem. Comm., 42, 1694-1704 (1977).
Alexandrova et al.(II), "Synthesis of Cytidylyl-(3'-5')-Cytidylyl-(3'-5')Adenosine Derivatives," Coll. Czech. Chem. Comm., 42, 1686-1693 (1977).
Gladkaya et al., "Synthesis of N,O-Protected Derivatives of 2'-O-Methylcytidine and 2'-O-Methyl- and N.sup.1 -Methylguanosines," Khim. Prir. Soedin., 1989(4), 568-573; Chem. Abstr., 112(21), p. 772, Abstr. No. 198947m (May 21, 1990).
Ishido et al., "Process for Synthesizing Oligonucleotides in a Homogeneous System Using Polysaccharide Derivatives as High Molecular Weight Protective Groups," PCT WO 88 03,149, published May 5, 1988; Chem. Abstr., 109(25), p. 910, Abstr. No. 231471q (Dec. 19, 1988); only abstract provided.
Rozners et al., "Synthesis of Oligoribonucleotides by the H-Phosphonate Method Using Base-Labile 2'-O-Protecting Groups. II. Some Aspects of Use of 2'-O-benzoyl and Anisoyl Protecting Groups," Bioorg. Khim., 16(11), 1531-1536 (1990).
Cotten et al., "2'-O-Methyl, 2'-O-Ethyl Oligoribonucleotides and Phosphorothioate Oligoribonucleotides as Inhibitors of the in vitro U7 snRNP-Dependent mRNA Processing Event," Nucleic Acids Res., 19(10), 2629-2635 (1991).
Caruthers et al., "Synthesis of Oligonucleotides Using the Phosphoramidite Method," in Biophosphates and Their Analogues--Synthesis, Structure, Metabolism and Activity, report of the Proceedings of the 2nd International Symposium on Phosphorus Chemistry Directed Towards Biology, Bruzik & Stec [Eds.], Lodz, Poland, Sep. 8-12, 1986, Elsevier Science Publishers, Amsterdam, The Netherlands, pp. 3-21.
Kierzek et al.(II), "Synthesis of 2'-5'-Oligoribonucleotides on Solid Support by Phosphoramidite Method," Biophosphates and Their Analogues--Synthesis, Structure, Metabolism and Activity, report of the Proceedings of the 2nd International Symposium on Phosphorus Chemistry Directed Towards Biology, Bruzik & Stec [Eds.], Lodz, Poland, Sep. 8-12, 1986, Elsevier Science Publishers, Amsterdam, The Netherlands, pp. 179-184.
Robins et al., "Nucleic Acid Related Compounds. 12. The Facile and High-Yield Stannous Chloride Catalyzed Monomethylation of the Cis-Glycol System of Nucleosides by Diazomethane," J. Org. Chem., 39(13), 1891-1899 (1974).
Heikkila et al., "5'-O-Trityl Groups Promoted Directive Effect in the Preparation of 2'-O-Methylribonucleosides," Acta Chemica Scand., B36(10), 715-717 (1982).
Vaghefi et al., "A Convenient High Yield Synthesis of N.sup.4 -Isobutyryl-2'-O-methylcytidine and its Monomer Units for Incorporation into Oligonucleotides," Nucleosides Nucleotides, 12(10), 1007-1013 (1993); Chem. Abstr., 121(1), p. 1049, Abstr. No. 9898y (Jul. 4, 1994); only Abstract provided.
Inoue et al. (II), "Sequence-dependent Hydrolysis of RNA Using Modified Oligonucleotide Splints and RNase H," FEBS Letters, 215(2), 327-330 (May 1987).
Sproat et al., "New Synthetic Routes to Protected Purine 2'-O-Methylriboside-3'-O-phosphoramidites Using a Novel Alkylation Procedure," Nucleic Acids Research, 18(1), 41-49 (1990).

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