Oligonucleotide modulation of protein kinase C

Details Oligonucleotide modulation of protein kinase C Oligonucleotide modulation of protein kinase C

1993-07-09

1997-12-30

Low, Christopher S. F.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 221, 536 231, 536 235, 536 241, 536 242, 536 243, 536 2431, 536 251, 536 252, 536 253, 536 2531, 935 6, 935 8, 935 9, 935 10, 935 11, 435194, A61K 3170

Patent

active

057030545

ABSTRACT:
Compositions and methods are provided for the treatment and diagnosis of diseases associated with protein kinase C. Oligonucleotides are provided which are specifically hybridizable with nucleic acid encoding PKC. Oligonucleotides specifically hybridizable with a translation initiation site, 5'-untranslated region or 3'-untranslated region are provided. Oligonucleotides specifically hybridizable with a particular PKC isozyme or set of isozymes are also provided. Methods of treating animals suffering from disease amenable to therapeutic intervention by modulating protein kinase C expression with an oligonucleotide specifically hybridizable with RNA or DNA corresponding to PKC are disclosed.

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