Oligonucleotide modulation of cell adhesion

Details Oligonucleotide modulation of cell adhesion Oligonucleotide modulation of cell adhesion

2005-02-01

2005-02-01

Shukla, Ram R. (Department: 1635)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C435S006120, C435S091100, C435S091310, C435S455000, C536S023100, C536S024500

Reexamination Certificate

active

06849612

ABSTRACT:
Compositions and methods for the treatment of ophthalmic disorders, particularly preservation of corneal explants and prevention of corneal allograft rejection. These compositions comprise oligonucleotides which are specifically hybridizable with nucleic acids encoding the cellular adhesion molecules intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and endothelial leukocyte adhesion molecule-1 (ELAM-1).

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Saison-Behmoaras B.T. et al. &

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