Oligonucleotide modulation of cell adhesion

Details Oligonucleotide modulation of cell adhesion Oligonucleotide modulation of cell adhesion

1993-01-21

1997-01-07

Rories, Charles C. P.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

536 245, 536 243, 536 2431, 536 2433, 514 44, 435 6, 435 721, C12N 522, C07H 2104, A61K 3170, C12Q 168

Patent

active

055916236

ABSTRACT:
Compositions and methods are provided for the treatment and diagnosis of diseases amenable to treatment through modulation of the synthesis or metabolism of intercellular adhesion molecules. In accordance with preferred embodiments, oligonucleotides are provided which are specifically hybridizable with nucleic acids encoding intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and endothelial leukocyte adhesion molecule-1. The oligonucleotide comprises nucleotide units sufficient in identity and number to effect said specific hybridization. In other preferred embodiments, the oligonucleotides are specifically hybridizable with a transcription initiation site, a translation initiation site, 5'-untranslated sequences, 3'-untranslated sequences, and intervening sequences. Methods of treating animals suffering from disease amenable to therapeutic intervention by modulating cell adhesion proteins with an oligonucleotide specifically hybridizable with RNA or DNA corresponding to one of the foregoing proteins are disclosed. Methods for treatment of diseases responding to modulation cell adhesion molecules are disclosed.

REFERENCES:
patent: 5034506 (1991-07-01), Summerton et al.
C. Mirabelli et al. Anti-Cancer Drug Design, vol. 6 (Dec. '91) pp. 647-661.
R. Zhang et al. PNAS, vol. 91 (Dec. '94) pp. 12755-12759.
W. Gibbs Scientific American, vol. of Oct. '94, pp. 133-134.
B. Tseng et al. Cancer Gene Therapy, vol. 1, No. 1 (Mar. '94) pp. 65-71.
P. Westermann et al. Biomed. Biochim. Acta, vol. 48, #1 ('89) pp. 85-93.
P. Eder et al. Antisense Research & Development, vol. 1 ('91) pp. 141-151.
L. Kibler-Herzog et al. Nucleic Acids Research, vol. 19, No. 11 ('91) pp. 2979-2986.
C. Stein et al. Science, vol. 261 (Aug. 20, 1993) pp. 1004-1012.
R. Weiss, Science News, vol. 139 (Feb. 16, 1991) pp. 108-109.
M. Cooney et al. Science, vol. 241, (1988) pp. 456-459.
E. Uhlmann et al. Chemical Reviews, vol. 90, #4, (1990) pp. 543-584.
P. S. Miller et al. Anti-Cancer Drug Design, vol. 2 (1987) pp. 117-128.
C. A. Stein et al. Cancer Research, vol. 48 (1988) pp. 2659-2668.
J. Goodchild et al. P.N.A.S., vol. 85 (1988) pp. 5507-5511.
Adams et al., "Intercellular Adhesion Molecule 1 on Liver Allografts During Rejection," Lancet, 1122-1125, Nov. 11, 1989.
Anderson and Springer, "Leukocyte Adhesion Deficiency: An Inherited Defect in the Mac-1, LFA-1, and p150,95 Glycoproteins," Ann. Rev. Med. 38:175-194, 1987.
Bevilacqua et al., "Endothelial Leukocyte Adhesion Molecule 1: An Inducible Receptor for Neutrophils Related to Complement Regulatory Proteins and Lectins," Science, 243:1160-1165, 1989.
Campbell et al., "Intercellular adhesion molecule 1 is induced on isolated endocrine islet cells by cytokines but not by reovirus infection," Proc. Natl. Acad. Sci. U.S.A., 86:4282-4286, 1989.
Dustin and Springer, "Lymphocyte Function-associated Antigen-1 (LFA-1) Interaction with Intercellular Adhesion Molecule-1 (ICAM-1) is One of At Least Three Mechanisms for Lymphocyte Adhesion to Cultured Endothelial Cells," J. Cell Biol., 107:321-331, 1987.
Faull and Russ, "Tubular Expression of Intercellular Adhesion Molecule-1 During Renal Allograft Rejection," Transplantation, 48:226-230, 1989.
Greve et al., "The Major Human Rhinovirus Receptor is ICAM-1," Cell, 56:839-847, 1989.
Griffiths and Nickoloff, "Keratinocyte Intercellular Adhesion Molecule-1 (ICAM-1) Expression Precedes Dermal T Lymphocyte Infiltration in Allergic Contact Dermatitis (Rhus dermatitis)," Am. J. Pathology, 135:1045-1053, 1989.
Harlan, J. M., "Leukocyte-Endothelial Interactions," Blood 65:513-525, 1985.
Ho et al., "Treatment of severe lichen planus with cyclosporine," J. Am. Acad. Dermatol., 22:64-68, 1990.
Lisby et al., "Intercellular adhesion molecule-1 (ICAM-1) expression correlated to inflammation," Br. J. Dermatol., 120:479-484, 1989.
Marlin et al., "A soluble form of intercellular adhesion molecule-1 inhibits rhinovirus infection," Nature, 344:70-72, 1990.
Osborn et al., "Direct Expression Cloning of Vascular Cell Adhesion Molecule 1, a Cytokine-Induced Endothelial Protein That Binds to Lymphocytes," Cell, 59:1203-1211, 1989.
Rice and Bevilacqua, "An Inducible Endothelial Cell Surface Glycoprotein Mediates Melanoma Adhesion," Science, 246:1303-1306, 1989.
Rice et al., "Inducible Cell Adhesion Molecule 110 (INCAM-110) is an Endothelial Receptor for Lymphocytes," J. Exp. Med., 171:1369-1374, 1990.
Rothenberg et al., "Oligodeoxynucleotides as Anti-Sense Inhibitors of Gene Expression: Therapeutic Implications," J. Natl. Cancer Inst., 81:1539-1544, 1989.
Staunton et al., "A Cell Adhesion Molecule, ICAM-1, Is the Major Surface Receptor for Rhinoviruses," Cell, 56:849-853, 1989.
Staunton et al., "The Arrangement of the Immunoglobulin-like Domains of ICAM-1 and the Binding Sites for LFA-1 and Rhinovirus," Cell, 61:243-354, 1990.
Shiohara et al., "Fixed Drug Eruption," Arch. Dermatol., 125: 1371-1376, 1989.
Weetman et al., "Expression of an intercellular adhesion molecule, ICAM-1, by human thyroid cells," J. Endocrinol., 122:185-191, 1989.
Wegner et al., "Intercellular Adhesion Molecule-1 (ICAM-1) in the Pathogenesis of Asthma," Science, 247:456-459, 1990.
Wellicome et al., "A Monoclonal Antibody that Detects A Novel Antigen on Endothelial Cells is Induced by Tumor Necrosis Factor, IL-1, or Lipopolysaccharide," J. Immunol., 144:2558-2565, 1990.
Zuker, M. "On Finding All Suboptimal Foldings of an RNA Molecule," Science, 244:48-52, 1989.
Bevilacqua et al., "Identification of an inducible endothelial-leukocyte adhesion molecule," Proc. Natl. Acad. Sci. USA, 84:9238-9242, 1987.
Cosimi et al., "In Vivo Effects of Monoclonal Antibody to ICAM-1 (CD54) in Nonhuman Primates with Renal Allografts," J. Immunol., 144:4604-4612, 1990.
Frohman, et al., "The induction of intercellular adhesion molecule 1 (ICAM-1) expression on human fetal astrocytes by interferon-.gamma., tumor necrosis factor .alpha., lymphotoxin, and interleukin-1: relevance to intracerebral antigen presentation," J. Neuroimmunol., 23:117-124, 1989.
Petersheim, M. and D. H. Turner, "Base-Stacking and Base-Pairing Contributions to Helix Stability: Thermodynamics of Double-Helix Formation with CCGG, CCGGp, CCGGAp, ACCGGp, CCGGUp, and ACCGGUp," Biochemistry, 22:256-263, 1983.
Zon, G. "Oligonucleotides Analogues as Potential Chemotherapeutic Agents," Pharmaceutical Res., 5:539-549, 1988.
Hale et al., "Immunohistologic Analysis of the Distribution of Cell Adhesion Molecules within the Inflammatory Synovial Microenvironment," Arth. Rheum., 32:22-30, 1989.
Staunton et al., "Primary Structure of ICAM-1 Demonstrates Interaction between Members of the Immunoglobulin and Integrin Supergene Families," Cell, 52:925-933, 1988.
Nielsen, Peter E., et al., "Sequence-Selective Recognition of DNA by Strand Displacement with a Thymine-Substituted Polyamide," Science, 254:1497-1500, 1991.

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