Oligonucleotide inhibitors of MBD2/DNA demethylase and uses...

Details Oligonucleotide inhibitors of MBD2/DNA demethylase and uses... Oligonucleotide inhibitors of MBD2/DNA demethylase and uses...

2003-06-20

2008-12-16

Angell, J. E. (Department: 1635)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C536S023100, C536S024500, C435S325000, C435S333000

Reexamination Certificate

active

07465714

ABSTRACT:
Oligonucleotide inhibitors that inhibit expression of a mammalian MBD2/DNA demethylase (MBD2/dMTase) are provided. The oligonucleotide inhibitors can be used to inhibit the growth or proliferation of tumor cells in vitro and in vivo. The use of the oligonucleotide inhibitors in the treatment of cancer and methods of identifying potential target genes for cancer therapy or diagnosis using the oligonucleotide inhibitors are also provided.

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